ReviewFrontiers in plant science2016
Carotenoids in Staple Cereals: Metabolism, Regulation, and Genetic Manipulation.
Review in Frontiers in plant science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 84 citations in OpenAlex.
- Gene-Editing-Mediated Enhancement of Carotenoid Compound Accumulation in Common Wheat Grains.Foods (Basel, Switzerland) · 2026Article
- Genome-wide association study and linkage mapping reveal TaqW-6B associated with water-extractable arabinoxylan content in wheat grain.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Activation of the native PHYTOENE SYNTHASE 1 promoter by modifying near-miss cis-acting elements induces carotenoid biosynthesis in embryogenic rice callus.Plant cell reports · 2024Article
- Characteristics of Oat and Buckwheat Malt Grains for Use in the Production of Fermented Foods.Foods (Basel, Switzerland) · 2023Article
- A multi-omic resource of wheat seed tissues for nutrient deposition and improvement for human health.Scientific data · 2023Article
- Unraveling transcriptomics of sorghum grain carotenoids: a step forward for biofortification.BMC genomics · 2023Article
- Genetic dissection of lutein content in common wheat via association and linkage mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Rice carotenoid biofortification and yield improvement conferred by endosperm-specific overexpression ofFrontiers in plant science · 2022Article
- Enrichment of provitamin A content in durum wheat grain by suppressing β-carotene hydroxylase 1 genes with a TILLING approach.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- GmCCD4 controls carotenoid content in soybeans.Plant biotechnology journal · 2021Article
- Low expression of carotenoids cleavage dioxygenase 1 (ccd1) gene improves the retention of provitamin-A in maize grains during storage.Molecular genetics and genomics : MGG · 2021Article
- Environmentally Driven Color Variation in the Pearl OysterFrontiers in genetics · 2021Article
- Comparative Proteomic Analysis by iTRAQ Reveals that Plastid Pigment Metabolism Contributes to Leaf Color Changes in Tobacco (International journal of molecular sciences · 2020Article
- Advancing provitamin A biofortification in sorghum: Genome-wide association studies of grain carotenoids in global germplasm.The plant genome · 2020Article
- Article
- Improving Photosynthetic Capacity, Alleviating Photosynthetic Inhibition and Oxidative Stress Under Low Temperature Stress With Exogenous Hydrogen Sulfide in Blueberry Seedlings.Frontiers in plant science · 2020Article
- Keeping an Eye on Lutein Stability.The Plant cell · 2019Article
- A GDSL Esterase/Lipase Catalyzes the Esterification of Lutein in Bread Wheat.The Plant cell · 2019Article
- Carotenoids in Cereal Food Crops: Composition and Retention throughout Grain Storage and Food Processing.Plants (Basel, Switzerland) · 2019Review
- Provitamin A Biofortification of Durum Wheat through a TILLING Approach.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotenoids play a critical role in animal and human health. Animals and humans are unable to synthesize carotenoids de novo, and therefore rely upon diet as sources of these compounds. However, major staple cereals often contain only small amounts of carotenoids in their grains. Consequently, there is considerable interest in genetic manipulation of carotenoid content in cereal grain. In this review, we focus on carotenoid metabolism and regulation in non-green plant tissues, as well as genetic manipulation in staple cereals such as rice, maize, and wheat. Significant progress has been made in three aspects: (1) seven carotenogenes play vital roles in carotenoid regulation in non-green plant tissues, including 1-deoxyxylulose-5-phosphate synthase influencing isoprenoid precursor supply, phytoene synthase, β-cyclase, and ε-cyclase controlling biosynthesis, 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase and carotenoid cleavage dioxygenases responsible for degradation, and orange gene conditioning sequestration sink; (2) provitamin A-biofortified crops, such as rice and maize, were developed by either metabolic engineering or marker-assisted breeding; (3) quantitative trait loci for carotenoid content on chromosomes 3B, 7A, and 7B were consistently identified, eight carotenogenes including 23 loci were detected, and 10 gene-specific markers for carotenoid accumulation were developed and applied in wheat improvement. A comprehensive and deeper understanding of the regulatory mechanisms of carotenoid metabolism in crops will be beneficial in improving our precision in improving carotenoid contents. Genomic selection and gene editing are emerging as transformative technologies for provitamin A biofortification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.