ArticleThe Journal of manual & manipulative therapy2016
Medium term effects of including manual therapy in a pulmonary rehabilitation program for chronic obstructive pulmonary disease (COPD): a randomized controlled pilot trial.
Article in The Journal of manual & manipulative therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Mind-body exercise for patients with stable COPD on lung function and exercise capacity: a systematic review and meta-analysis of RCTs.Scientific reports · 2024Pooled it
- The efficacy of manual therapy for chronic obstructive pulmonary disease: A systematic review.PloS one · 2021Pooled it
- Do manual therapies have a specific autonomic effect? An overview of systematic reviews.PloS one · 2021Pooled it
- Muscle energy technique for chronic obstructive pulmonary disease: a systematic review.Chiropractic & manual therapies · 2019Pooled it
- The Use of Spinal Manipulative Therapy in the Management of Chronic Obstructive Pulmonary Disease: A Systematic Review.Journal of alternative and complementary medicine (New York, N.Y.) · 2016Pooled it
- Effectiveness of 12-week inspiratory muscle training with manual therapy in patients with COPD: A randomized controlled study.The clinical respiratory journal · 2022Trial
- Trial
- The immediate effect of soft tissue manual therapy intervention on lung function in severe chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2017Trial
- Effects of Manual Therapy on Respiratory Function in Healthy Individuals: A Randomized, Sham-Controlled Clinical Trial of Efficacy and Safety.Healthcare (Basel, Switzerland) · 2026Article
- Adding Manual Therapy to a Respiratory-Rehabilitation Program in Patients with Respiratory Disorders: A Systematic Review and Meta-Analysis with a Meta-Regression.Journal of chiropractic medicine · 2025Review
- Comparative effectiveness of manual therapy and band exercises combined with high-intensity walking for pain, posture, and cardiorespiratory health in older adults: a randomised clinical trial.Frontiers in medicine · 2025Article
- Review
- Comparative Effectiveness of Western and Eastern Manual Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis.Healthcare (Basel, Switzerland) · 2021Review
- Perceptions and experiences of a manual therapy trial: a qualitative study of people with moderate to severe COPD.Chiropractic & manual therapies · 2021Article
- Exercise Training in Patients with Chronic Respiratory Diseases: Are Cardiovascular Comorbidities and Outcomes Taken into Account?-A Systematic Review.Journal of clinical medicine · 2019Review
- Article
- The Role of Manual Therapy in Patients with COPD.Healthcare (Basel, Switzerland) · 2019Review
- Safety of thrust joint manipulation in the thoracic spine: a systematic review.The Journal of manual & manipulative therapy · 2015Article
- The importance of epistemological consideration in the reporting of evidence for osteopathic care in Covid-19 papers.Explore (New York, N.Y.)Article
- The importance of rigour in the reporting of evidence for osteopathic care in Covid-19 papers.Explore (New York, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designRandomized clinical trial.
objectiveTo investigate the effect of including manual therapy (MT) in a pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD).
backgroundThe primary source of exercise limitation in people with COPD is dyspnea. The dyspnea is partly caused by changes in chest wall mechanics, with an increase in chest wall rigidity (CWR) contributing to a decrease in lung function. As MT is known to increase joint mobility, administering MT to people with COPD carries with it the potential to influence CWR and lung function.
methodsThirty-three participants with COPD, aged between 55 and 70 years (mean = 65·5±4 years), were randomly assigned to three groups: pulmonary rehabilitation (PR) only, soft tissue therapy (ST) and PR, and ST, spinal manipulative therapy (SM), and PR. Outcome measures including forced expiratory volume in the 1st second (FEV1), forced vital capacity (FVC), 6-minute walking test (6MWT), St. George's respiratory questionnaire (SGRQ), and the hospital anxiety and depression (HAD) scale were recorded at 0, 8, 16, and 24 weeks.
resultsThere was a significant difference in FVC between the three groups at 24 weeks (P = 0·04). For the ST+SM+PR group versus PR only the increase was 0·40 l (CI: 0·02, 0·79; P = 0·03). No major or moderate adverse events (AE) were reported following the administration of 131 ST and 272 SM interventions. DISCUSSION: The increase in FVC is a unique finding. Although the underlying mechanisms responsible for this outcome are not yet understood, the most likely explanation is the synergistic effect resulting from the combination of interventions. These results support the call for a larger clinical trial in the use of MT for COPD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.