ReviewJournal of toxicologic pathology2016
A comparison of the anatomical structure of the pancreas in experimental animals.
Review in Journal of toxicologic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 63 citations in OpenAlex.
- Adult canine pancreatic organoids enable functional analysis of pancreatic epithelial barrier and inflammatory responses.BMC molecular and cell biology · 2026Article
- Histological distribution of endocrine cells in the pancreas of Javan Mongoose (Open veterinary journal · 2026Article
- Acute pancreatitis experimental models, advantages and disadvantages.Journal of physiology and biochemistry · 2025Review
- Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems.Frontiers in cell and developmental biology · 2025Article
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of Nonrodent Ocular Tissues.Toxicologic pathology · 2024Review
- Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.Pituitary · 2024Article
- Article
- Comparative study of pancreatic vessels and mesopancreas of rhesus monkeys and humans.Frontiers in surgery · 2023Article
- Review
- Article
- Pancreatic β-Cell Development and Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Schwann Cells in Digestive System Disorders.Cells · 2022Review
- High-intensity infrasound effects on glucose metabolism in rats.Scientific reports · 2021Article
- Dynamics of total volume of pancreatic α- and β -cells under the influence sulfonylureas and their combination with dipeptidyl peptidase-4 inhibitors.Endocrinology, diabetes & metabolism · 2021Article
- Intercellular Communication in the Islet of Langerhans in Health and Disease.Comprehensive Physiology · 2021Article
- International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (Journal of toxicologic pathology · 2021Review
- Developmental effects ofTrends in developmental biology · 2021Article
- A 90 day oral toxicity study of blueberry polyphenols in ovariectomized sprague-dawley rats.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020Article
- Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion.Experimental animals · 2020Article
- Production, Characterization, and Function of Pseudoislets from Perinatal Canine Pancreas.Cell transplantation · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As basic knowledge for evaluation of pancreatic toxicity, anatomical structures were compared among experimental animal species, including rats, dogs, monkeys, and minipigs. In terms of gross anatomy, the pancreases of dogs, monkeys, and minipigs are compact and similar to that of humans. The rat pancreas is relatively compact at the splenic segment, but the duodenal segment is dispersed within the mesentery. In terms of histology, the islet of each animal is characterized by a topographic distribution pattern of α- versus β-cells. β-cells occupy the large central part of the rat islet, and α-cells are located in the periphery and occasionally exhibit cuffing. In dog islets, β-cells are distributed in all parts and α-cells are scattered in the center or periphery of the islet (at body and left lobe); whereas β-cells occupy all parts of the islet and no α-cells are present in the islet (at right lobe). Monkey islets show two distinct patterns, that is, α-cell-rich or β-cell-rich islets, and the former represent peripheral β-cells forming an irregular ring. Minipig islets show an irregular outline, and both α- and β-cells are present in all parts of the islet, intermingling with each other. According to morphometry, the endocrine tissue accounts for <2% of the pancreas roughly in rats and minipigs, and that of monkeys accounts for >7% of the pancreas (at tail). The endocrine tissue proportion tends to increase as the position changes from right to left in the pancreas in each species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.