ArticleJournal of the American Heart Association2016
Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort.
Article in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association Between Asthma and All-Cause Mortality and Cardiovascular Disease Morbidity and Mortality: A Meta-Analysis of Cohort Studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Effects of Comorbidities on Asthma Hospitalization and Mortality Rates: A Systematic Review.Canadian respiratory journal · 2018Pooled it
- Asthma and the risk of cardiovascular diseases and mortality: a meta-analysis of cohort studies.Therapeutic advances in respiratory diseasePooled it
- Association of Immunoglobulin E With Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.Pulmonary circulation · 2026Article
- New insights on pharmacological potential of montelukast: a comprehensive review.Inflammopharmacology · 2025Review
- Demographic and regional analysis of 22 years of mortality data from coexisting asthma and cardiovascular disease in the United States.Proceedings (Baylor University. Medical Center) · 2025Article
- Association between COVID-19 vaccination and atopic diseases in US adults: A retrospective cohort study.PloS one · 2025Article
- Obstructive Airway Disease is Associated with Increased Cardiovascular Disease Risk Independent of Phenotype: Evidence from Two Nationwide Population-Based Studies.International journal of chronic obstructive pulmonary disease · 2025Article
- Blood eosinophil count is associated with early atherosclerotic artery changes in asthma.BMC pulmonary medicine · 2024Article
- Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024Review
- Emergent Inflammatory Markers and Echocardiographic Indices in Patients with Bronchial Asthma.Biomolecules · 2023Article
- Comorbidities in childhood-onset and adult-onset asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Increased Oxidative Stress in Asthma-Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices.Biomedicines · 2022Article
- Allergic asthma is a risk factor for human cardiovascular diseases.Nature cardiovascular research · 2022Review
- Article
- Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study.Scientific reports · 2021Article
- Shared Genetic Architecture and Causal Relationship Between Asthma and Cardiovascular Diseases: A Large-Scale Cross-Trait Analysis.Frontiers in genetics · 2021Article
- Article
- Effects of allergic airway inflammation and chronic intermittent hypoxia on systemic blood pressure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Prognostic role of bronchial asthma in patients with heart failure.Heart and vessels · 2020Observational
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAsthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late-onset subtype of asthma is associated with a higher risk of incident CVD. METHODS AND
resultsParticipants from the Wisconsin Sleep Cohort free of CVD at baseline were followed for a mean (SD) of 13.9 (5.9) years for development of CVD (myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Late-onset asthma was defined as physician-diagnosed asthma at age ≥18 years. Multivariable Cox regression models adjusted for age, sex, and CVD risk factors were used to assess associations of late-onset asthma and incident CVD. The 1269 participants were 47.3 (8.0) years old; 166 participants had asthma (111 late-onset, 55 early-onset). Participants with late-onset asthma compared to nonasthmatics were more likely to be female (67% versus 44%) and to have a higher body-mass index (32.2 versus 29.4 kg/m(2)) (P<0.05). Mean age of asthma diagnosis in the late-onset group was 39.5 (9.6) years versus 8.9 (5.7) years in the early-onset group (P<0.0001). Late-onset asthmatics had a higher adjusted risk of incident CVD than nonasthmatics (hazard ratio 1.57, 95% CI 1.01-2.45, P=0.045). There was no interaction between body-mass index and age of asthma diagnosis on incident CVD (P=0.83).
conclusionsIn a large cohort study of adults followed prospectively for over a decade, late-onset asthmatics had an increased risk of incident CVD events that persisted after adjustment for age, sex, and CVD risk factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.