ArticleJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi2016
Influence of amino acids on gastric adaptive relaxation (accommodation) in rats as evaluated with a barostat.
Article in Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Vagus nerve stimulation promotes gastric emptying by increasing pyloric opening measured with magnetic resonance imaging.Neurogastroenterology and motility · 2018Article
- Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids.Journal of neurogastroenterology and motility · 2017Article
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2 authors at 1 institution in 1 country.
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Abstract
aimThe present study aimed to evaluate the effects of selected straight alkyl chain, hydroxylated chain and branched chain amino acids on gastric adaptive relaxation, as these have previously been shown to have differing effects on gastric emptying. MATERIALS AND
methodsGastric adaptive relaxation was evaluated using a barostat in rats under urethane anesthesia. The pressure within the balloon, introduced from the mouth to the stomach, was changed stepwise from 1 to 8 mmHg. The increased volume just after the increase of balloon pressure was defined as distension-induced gastric adaptive relaxation (accommodation). Amino acids were administered orally or intravenously.
resultsAs compared with control rats administered with distilled water, those rats that were orally administered amino acids having straight alkyl chain and extra hydroxylated alkyl chain, such as glycine and l-serine, had significantly enhanced gastric adaptive relaxation, but administration of l-alanine and l-threonine did not. Branched chain amino acids, such as l-isoleucine, l-leucine and l-valine, also did not significantly influence gastric adaptive relaxation. Glycine and l-serine showed the same efficacy when administered intravenously.
conclusionAmong the amino acids evaluated in the present study, glycine and l-serine significantly enhanced gastric adaptive relaxation, suggesting that short alkyl chain amino acids may enhance gastric adaptive relaxation as compared with the other amino acids. These findings may suggest that glycine and l-serine would be useful in the therapy of functional dyspepsia, especially for early satiety, because the dysfunction of adaptive relaxation is one of the causes of early satiety.
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