SynthesisScientific reports2016
Diagnostic performance of serum IgG4 level for IgG4-related disease: a meta-analysis.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic accuracy of IgG 4/IgG and IgG 4 in patients with IgG 4-related disease: a meta-analysis.Zeitschrift fur Rheumatologie · 2025Pooled it
- Spontaneously Resolving Pancreatic IgG4-Related Disease Representing With Systemic Involvement and Membranous Nephropathy.Kidney medicine · 2026Article
- Article
- Bilateral Sialadenitis as an Uncommon Initial Manifestation of Infectious Mononucleosis.Internal medicine (Tokyo, Japan) · 2024Article
- Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population.Arthritis research & therapy · 2024Article
- Myofibroblast and pro-fibrotic cytokines in fibrosis of IgG4-related disease (IgG4-RD) patients from South Asia: preliminary data.Clinical rheumatology · 2024Article
- Immunoglobulin G4 in primary Sjögren's syndrome and IgG4-related disease - connections and dissimilarities.Frontiers in immunology · 2024Review
- Clinical Significance of Serum IgG4 in the Diagnosis and Treatment Response of IgG4-Related Disease in Adults of Southwest China: A Retrospective Study.Annals of laboratory medicine · 2023Article
- A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease.Internal medicine (Tokyo, Japan) · 2023Article
- Long-Term Follow-Up in IgG4-Related Ophthalmic Disease: Serum IgG4 Levels and Their Clinical Relevance.Journal of personalized medicine · 2022Article
- A case of prominent immunoglobulin G4-positive lymphadenopathy in response to microscopic lung cancer.Respirology case reports · 2021Article
- Establishment of time-resolved fluoroimmunoassay of IgG4 based on magnetic microspheres.Journal of clinical laboratory analysis · 2021Article
- IgG4-related disease: Changing epidemiology and new thoughts on a multisystem disease.Journal of translational autoimmunity · 2021Review
- Validation of a Multiplex Assay for Measuring Specific IgG4.Yonsei medical journal · 2020Article
- Increased Circulating Th1 and Tfh1 Cell Numbers Are Associated with Disease Activity in Glucocorticoid-Treated Patients with IgG4-Related Disease.Journal of immunology research · 2020Article
- Retrospective single-centre analysis of IgG4-related disease patient population and treatment outcomes between 2007 and 2017.Rheumatology advances in practice · 2019Article
- Diagnostic and treatment workup for IgG4-related disease.Expert review of clinical immunology · 2017Review
- Immunoglobulin-G4 related mastitis: A case report.International journal of surgery case reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An elevated serum IgG4 level is one of the most useful factors in the diagnosis of IgG4-related disease (IgG4-RD). In this study, we performed a meta-analysis of the published articles assessing the diagnostic accuracy of serum IgG4 concentrations for IgG4-RD. The databases of MEDLINE/PubMed, EMBASE and Web of Science were systematically searched for relevant studies. Sensitivities and specificities of serum IgG4 in each study were calculated, and the hierarchical summary receiver operating characteristic (HSROC) model with a random effects model were employed to obtain the individual and pooled estimates of sensitivities and specificities. In total, twenty-three studies comprising 6048 patients with IgG4-RD were included in the meta-analysis. The pooled sensitivity was 85% with a 95% confidence interval (CI) of 78-90%; the pooled specificity was 93% with a 95% CI of 90-95%. The HSROC curve for quantitative serum IgG4 lies closer to the upper left corner of the plot, and the area under the curve (AUC) was 0.95 (95% CI 0.93, 0.97), which suggested a high diagnostic accuracy of serum IgG4 for the entity of IgG4-RD. Our study suggests that serum IgG4 has high sensitivity and specificity in the diagnosis of IgG4-RD.
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Registered trials
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