ArticleJournal of toxicology and environmental health. Part A2016
Pulmonary exposure to cellulose nanocrystals caused deleterious effects to reproductive system in male mice.
Article in Journal of toxicology and environmental health. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Morphometric Characteristics of Rat Testes Tissue After Exposure to Dust-Salt Aerosols of the Aral Sea.Biology · 2025Article
- Passive physical barrier modulates UVB-induced METosis-related MPO expression and activity, 25-hydroxyvitamin D3-1alpha-hydroxylase, and the shift of tissue-resident macrophages toward M1-associated iNOS.Frontiers in immunology · 2025Article
- Tackling the cytotoxicity and genotoxicity of cellulose nanofibers from the banana rachis: A new food packaging alternative.Heliyon · 2023Article
- Nanocelluloses - Nanotoxicology, Safety Aspects and 3D Bioprinting.Advances in experimental medicine and biology · 2022Review
- Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications.Pharmaceutics · 2021Review
- Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats.Inhalation toxicology · 2021Article
- Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.Frontiers in bioengineering and biotechnology · 2021Review
- Nanocellulose Bio-Based Composites for Food Packaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Histomorphological and Redox Delineations in the Testis and Epididymis of Albino Rats Fed with Green-Synthesized Cellulose.Biology · 2020Article
- Screening of preservatives and evaluation of sterilized cellulose nanofibers for toxicity studies.Journal of occupational health · 2020Article
- The Crystallinity and Aspect Ratio of Cellulose Nanomaterials Determine Their Pro-Inflammatory and Immune Adjuvant Effects In Vitro and In Vivo.Small (Weinheim an der Bergstrasse, Germany) · 2019Article
- Risk Analysis of Cellulose Nanomaterials by Inhalation: Current State of Science.Nanomaterials (Basel, Switzerland) · 2019Review
- Development of high throughput, high precision synthesis platforms and characterization methodologies for toxicological studies of nanocellulose.Cellulose (London, England) · 2018Article
- Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity.Journal of toxicology and environmental health. Part A · 2017Article
- A critical review of the current knowledge regarding the biological impact of nanocellulose.Journal of nanobiotechnology · 2016Review
- Comment on Shvedova et al. (2016), "gender differences in murine pulmonary responses elicited by cellulose nanocrystals".Particle and fibre toxicology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Over the past several years there has been an increased number of applications of cellulosic materials in many sectors, including the food industry, cosmetics, and pharmaceuticals. However, to date, there are few studies investigating the potential adverse effects of cellulose nanocrystals (CNC). The objective of this study was to determine long-term outcomes on the male reproductive system of mice upon repeated pharyngeal aspiration exposure to CNC. To achieve this, cauda epididymal sperm samples were analyzed for sperm concentration, motility, morphological abnormalities, and DNA damage. Testicular and epididymal oxidative damage was evaluated, as well as histopathology examination of testes. In addition, changes in levels of testosterone in testes and serum and of luteinizing hormone (LH) in serum were determined. Three months after the last administration, CNC exposure significantly altered sperm concentration, motility, cell morphology, and sperm DNA integrity. These parameters correlated with elevated proinflammatory cytokines levels and myeloperoxidase (MPO) activity in testes, as well as oxidative stress in both testes and epididymis. Exposure to CNC also produced damage to testicular structure, as evidenced by presence of interstitial edema, frequent dystrophic seminiferous tubules with arrested spermatogenesis and degenerating spermatocytes, and imbalance in levels of testosterone and LH. Taken together, these results demonstrate that pulmonary exposure to CNC induces sustained adverse effects in spermatocytes/spermatozoa, suggesting male reproductive toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.