Evidence map›Paper›PMID 27558804›Full record

ArticleToxicology letters2016

Pleiotropic roles of Ca

Thao T Ha, Shalimar T Burwell, Matthew L Goodwin, Jacob A Noeker, Sara J Heggland

Abstract read
In one paragraph

Article in Toxicology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium.Environmental science and pollution research international · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Activation of CaScientific reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Thao T HaDepartment of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA.
Shalimar T BurwellDepartment of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA.
Matthew L GoodwinDepartment of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA.
Jacob A NoekerDepartment of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA.
Sara J HegglandDepartment of Biology, The College of Idaho, 2112 Cleveland Blvd, Caldwell, ID 83605, USA. Electronic address: sheggland@collegeofidaho.edu.
College of Idaho · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
NIGMS NIH HHS P20 GM103408
6 · The paper itself

Abstract

The heavy metal cadmium is a widespread environmental contaminant that has gained public attention due to the global increase in cadmium-containing electronic waste. Human exposure to cadmium is linked to the pathogenesis of osteoporosis. We previously reported cadmium induces apoptosis and decreases alkaline phosphatase mRNA expression via extracellular signal-regulated protein kinase (ERK) activation in Saos-2 bone-forming osteoblasts. This study examines the mechanisms of cadmium-induced osteotoxicity by investigating roles of Ca

Indexed as

ApoptosisBenzenesulfonamidesBenzimidazolesBenzylaminesBiomarkersCadmiumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCalmodulinCell Line, TumorCyclic Nucleotide Phosphodiesterases, Type 1Environmental PollutantsEnzyme ActivationHumansLethal Dose 50BenzenesulfonamidesBenzimidazolesBenzylaminesBiomarkersCadmiumCalcium-Calmodulin-Dependent Protein Kinase KinaseCalcium-Calmodulin-Dependent Protein Kinase Type 2CALM1 protein, humanCalmodulinCGS 9343BCyclic Nucleotide Phosphodiesterases, Type 1Environmental PollutantsKN 93NaphthalimidesPhosphodiesterase InhibitorsProtein Kinase InhibitorsSTO 609SulfonamidesApoptosisCadmiumCalmodulinOsteoblast

Identifiers

PMID27558804
PMCPMC5671922
OpenAlexW2513330586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.