Trial reportBritish journal of clinical pharmacology2017
Population pharmacokinetics and analgesic potency of oxycodone.
Trial report in British journal of clinical pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Oxycodone Effect on Pupil Constriction in Recreational Opioid Users: A Pharmacokinetic/Pharmacodynamic Meta-Analysis Approach.Clinical pharmacokinetics · 2021Pooled it
- Low skeletal muscle mass and postoperative morbidity in surgical oncology: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2020Pooled it
- Analgesic efficacy and pharmacokinetics of epidural oxycodone in pain management after gynaecological laparoscopy-A randomised, double blind, active control, double-dummy clinical comparison with intravenous administration.British journal of clinical pharmacology · 2019Trial
- Population pharmacokinetics and analgesic potency of oxycodone.British journal of clinical pharmacology · 2017Trial
- Characterization and validation of a spontaneous acute and protracted oxycodone withdrawal model in male and female mice.Pharmacology, biochemistry, and behavior · 2024Article
- Population pharmacokinetics of nalbuphine in patients undergoing general anesthesia surgery.Frontiers in pharmacology · 2023Article
- Pharmacokinetic Pharmacodynamic Modelling Contributions to Improve Paediatric Anaesthesia Practice.Journal of clinical medicine · 2022Review
- Epidural Oxycodone for Acute Pain.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function.Drug and alcohol dependence · 2021Article
- Different Doses of Oxycodone for Endoscopic Injection Sclerotherapy of Esophageal Varices.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- The Effect of Oxycodone on Post-operative Pain and Inflammatory Cytokine Release in Elderly Patients Undergoing Laparoscopic Gastrectomy.Frontiers in medicine · 2021Article
- Optimal effect-site concentration of remifentanil to prevent hemodynamic changes during nasotracheal intubation using a video laryngoscope.Journal of dental anesthesia and pain medicine · 2020Article
- Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone.Clinical pharmacokinetics · 2019Review
- Optimal effective-site concentration of remifentanil for sedation during plate removal of maxilla.Journal of dental anesthesia and pain medicine · 2018Article
- Observational
- Quantitative analysis of the effect of end-tidal carbon dioxide on regional cerebral oxygen saturation in patients undergoing carotid endarterectomy under general anaesthesia.British journal of clinical pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis prospective study aimed to characterize the population pharmacokinetics of intravenous oxycodone and to determine the minimum effective concentration (MEC) and minimum effective analgesic concentration (MEAC) of oxycodone for major open intra-abdominal surgery.
methodsIn the pharmacokinetic study, patients were administered intravenous oxycodone (0.1 mg kg
resultsIn the population pharmacokinetic study (n = 54), oxycodone plasma concentration over time was well described by a three-compartment mammillary model. Lean body mass and age were significant covariates for the volume of distribution and metabolic clearance of the pharmacokinetic model of oxycodone, respectively. The analgesic-potency study (n = 50) showed that the median (95% CI) MEC and MEAC were 31.5 (19.2-42.8) and 74.1 (29.2-128.3) ng ml
conclusionsIn major intra-abdominal open surgery, the MEAC and analgesic potency of oxycodone were 75 ng ml
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.