ArticleNature communications2016
Hedgehog-BMP signalling establishes dorsoventral patterning in lateral plate mesoderm to trigger gonadogenesis in chicken embryos.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 33 citations in OpenAlex.
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- Overview of Avian Sex Reversal.International journal of molecular sciences · 2023Review
- Effect of Hydrogen Oxide-Induced Oxidative Stress on Bone Formation in the Early Embryonic Development Stage of Chicken.Biomolecules · 2023Article
- Modeling Human Gonad Development in Organoids.Tissue engineering and regenerative medicine · 2022Article
- Review
- Time-Course Transcriptional and Chromatin Accessibility Profiling Reveals Genes Associated With Asymmetrical Gonadal Development in Chicken Embryos.Frontiers in cell and developmental biology · 2022Article
- Genetic Regulation of Avian Testis Development.Genes · 2021Review
- An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development.Stem cell reports · 2020Article
- A discrete subtype of neural progenitor crucial for cortical folding in the gyrencephalic mammalian brain.eLife · 2020Article
- Gonadal Sex Differentiation: Supporting Versus Steroidogenic Cell Lineage Specification in Mammals and Birds.Frontiers in cell and developmental biology · 2020Review
- Dicyemid Mesozoans: A Unique Parasitic Lifestyle and a Reduced Genome.Genome biology and evolution · 2019Article
- The Y Chromosome Takes the Field to Modify BMPR2 Expression.American journal of respiratory and critical care medicine · 2018Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gonad appears in the early embryo after several events: cells at the lateral plate mesoderm (LPM) undergo ingression, begin gonadal differentiation and then retain primordial germ cells (PGCs). Here we show that in the chicken embryo, these events are triggered on the basis of dorsoventral patterning at the medial LPM. Gonadal progenitor cells (GPCs) at the ventromedial LPM initiate gonadogenesis by undergoing ingression, whereas mesonephric capsule progenitor cells (MCPCs) at the dorsomedial LPM do not. These contrasting behaviours are caused by Hedgehog signalling, which is activated in GPCs but not in MCPCs. Inhibiting Hedgehog signalling prevents GPCs from forming gonadal structures and collecting PGCs. When activated by Hedgehog signalling, MCPCs form an ectopic gonad. This Hedgehog signalling is mediated by BMP4. These findings provide insight into embryonic patterning and gonadal initiation in the chicken embryo.
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