ArticleBiophysical journal2016
Costs of Clock-Environment Misalignment in Individual Cyanobacterial Cells.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Article
- Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation.NPJ systems biology and applications · 2025Article
- Environmental and molecular noise buffering by the cyanobacterial clock in individual cells.Nature communications · 2025Article
- Circa-SCOPE: high-throughput live single-cell imaging method for analysis of circadian clock resetting.Nature communications · 2021Article
- Light exposure mediates circadian rhythms of rhizosphere microbial communities.The ISME journal · 2021Article
- Article
- Spectres of Clock Evolution: Past, Present, and Yet to Come.Frontiers in physiology · 2021Review
- Daily Cycles of Reversible Protein Condensation in Cyanobacteria.Cell reports · 2020Article
- A Mechanistic Model of the Regulation of Division Timing by the Circadian Clock in Cyanobacteria.Biophysical journal · 2020Article
- Circadian clock helps cyanobacteria manage energy in coastal and high latitude ocean.The ISME journal · 2020Article
- Computational modelling unravels the precise clockwork of cyanobacteria.Interface focus · 2018Review
- Cell size control driven by the circadian clock and environment in cyanobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genome-wide fitness assessment during diurnal growth reveals an expanded role of the cyanobacterial circadian clock protein KaiA.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Unveiling "Musica Universalis" of the Cell: A Brief History of Biological 12-Hour Rhythms.Journal of the Endocrine Society · 2018Review
- Cellular trade-offs and optimal resource allocation during cyanobacterial diurnal growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Structural basis of the day-night transition in a bacterial circadian clock.Science (New York, N.Y.) · 2017Article
- Redox crisis underlies conditional light-dark lethality in cyanobacterial mutants that lack the circadian regulator, RpaA.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Heterotroph Interactions AltermSystemsArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Circadian rhythms are endogenously generated daily oscillations in physiology that are found in all kingdoms of life. Experimental studies have shown that the fitness of Synechococcus elongatus, a photosynthetic microorganism, is severely affected in non-24-h environments. However, it has been difficult to study the effects of clock-environment mismatch on cellular physiology because such measurements require a precise determination of both clock state and growth rate in the same cell. Here, we designed a microscopy platform that allows us to expose cyanobacterial cells to pulses of light and dark while quantitatively measuring their growth, division rate, and circadian clock state over many days. Our measurements reveal that decreased fitness can result from a catastrophic growth arrest caused by unexpected darkness in a small subset of cells with incorrect clock times corresponding to the subjective morning. We find that the clock generates rhythms in the instantaneous growth rate of the cell, and that the time of darkness vulnerability coincides with the time of most rapid growth. Thus, the clock mediates a fundamental trade-off between growth and starvation tolerance in cycling environments. By measuring the response of the circadian rhythm to dark pulses of varying lengths, we constrain a mathematical model of a population's fitness under arbitrary light/dark schedules. This model predicts that the circadian clock is only advantageous in highly regular cycling environments with frequencies sufficiently close to the natural frequency of the clock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.