ArticleBiophysical journal2016
Investigating the Structure of Multicomponent Gel-Phase Lipid Bilayers.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Combination of Molecular Dynamics Simulations and Machine Learning Reveals Structural Characteristics of Stereochemistry-Specific Interdigitation of Synthetic Monomycoloyl Glycerol Analogs.Journal of chemical information and modeling · 2025Article
- Hydration- and Temperature-Dependent Fluorescence Spectra of Laurdan Conformers in a DPPC Membrane.Cells · 2024Article
- Dissimilar Deformation of Fluid- and Gel-Phase Liposomes upon Multivalent Interaction with Cell Membrane Mimics Revealed Using Dual-Wavelength Surface Plasmon Resonance.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Examining Tail and Headgroup Effects on Binary and Ternary Gel-Phase Lipid Bilayer Structure.The journal of physical chemistry. B · 2020Article
- Clinical and in vitro evaluation of new anti-redness cosmetic products in subjects with winter xerosis and sensitive skin.International journal of cosmetic science · 2019Article
- Characterization of phospholipid vesicles containing lauric acid: physicochemical basis for process and product development.Heliyon · 2019Article
- Computational Modeling of Realistic Cell Membranes.Chemical reviews · 2019Review
- Composition Dependence of Water Permeation Across Multicomponent Gel-Phase Bilayers.The journal of physical chemistry. B · 2018Article
- Molecular dynamics simulations of stratum corneum lipid mixtures: A multiscale perspective.Biochemical and biophysical research communications · 2018Article
- Effect of Ceramide Tail Length on the Structure of Model Stratum Corneum Lipid Bilayers.Biophysical journal · 2018Article
- Polyphilic Interactions as Structural Driving Force Investigated by Molecular Dynamics Simulation (Project 7).Polymers · 2017Review
- Systems biology of cellular membranes: a convergence with biophysics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single- and multicomponent lipid bilayers of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), 1,2-distearoyl-sn-glycero-3-phosphatidylcholine (DSPC), isostearyl isostearate, and heptadecanoyl heptadecanoate in the gel phase are studied via molecular dynamics simulations. It is shown that the structural properties of multicomponent bilayers can deviate strongly from the structures of their single-component counterparts. Specifically, the lipid mixtures are shown to adopt a compact packing by offsetting the positioning depths at which different lipid species are located in the bilayer. This packing mechanism affects the area per lipid, the bilayer height, and the chain tilt angles and has important consequences for other bilayer properties, such as interfacial hydrogen bonding and bilayer permeability. In particular, the simulations suggest that bilayers containing isostearyl isostearate or heptadecanoyl heptadecanoate are less permeable than pure 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine or DSPC bilayers. Furthermore, hydrogen-bond analysis shows that the residence times of lipid-water hydrogen bonds depend strongly on the bilayer composition, with longer residence times for bilayers that have a higher DSPC content. The findings illustrate and explain the fundamental differences between the properties of single- and multicomponent bilayers.
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