Evidence map›Paper›PMID 27558700›Full record

ReviewCritical reviews in food science and nutrition2018

Vitamin D and its impact on maternal-fetal outcomes in pregnancy: A critical review.

Shreya Agarwal, Oormila Kovilam, Devendra K Agrawal

Abstract readReview
In one paragraph

Review in Critical reviews in food science and nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  18. Vitamin D and Intrauterine Growth Restriction (IUGR).International journal of molecular sciences · 2025
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  20. Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shreya Agarwala Department of Clinical & Translational Science , Creighton University School of Medicine , Omaha , Nebraska , USA.
Oormila Kovilamb Department of Obstetrics & Gynecology , Creighton University School of Medicine , Omaha , Nebraska , USA.
Devendra K Agrawala Department of Clinical & Translational Science , Creighton University School of Medicine , Omaha , Nebraska , USA.ORCID http://orcid.org/0000-0001-5445-0013

Funding

MESENCHYMAL STEM CELLS IN THE PREVENTION OF THROMBOSIS AND NEOINTIMAL HYPERPLASIAR01HL112597 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2012 to 2016
$3.8M
EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSISR01HL120659 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2013 to 2017
$3.6M
VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASER01HL116042 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2012 to 2016
$3.3M
NHLBI NIH HHS R01 HL112597NHLBI NIH HHS R01 HL116042NHLBI NIH HHS R01 HL120659
6 · The paper itself

Abstract

The role of vitamin D beyond its classical function in calcium homeostasis has been of significant interest in recent years. There has been expanding research on the pleiotropic role of vitamin D in pregnancy and the implications of its deficiency on maternal-fetal outcomes. Several studies have associated low maternal vitamin D status to adverse outcomes in pregnancy, including preeclampsia, gestational diabetes, preterm births, low birth weight, and others. Several randomized controlled clinical trials of Vitamin D supplementation during pregnancy have also been conducted. Though some of the studies found improvement in pregnancy outcomes with vitamin D supplementation, others have not shown any association. In this article, we have critically reviewed the observational and interventional studies, published primarily within the past two years (January 2014 to February 2016) on the influence of vitamin D deficiency on pregnancy and the impact of its supplementation. The potential underlying mechanisms of vitamin D in regulating each of the outcomes have also been discussed.

Indexed as

Dietary SupplementsPregnancy OutcomeFemaleHumansInfant, NewbornObservational Studies as TopicPregnancyPregnancy ComplicationsRandomized Controlled Trials as TopicVitamin DVitamin D DeficiencyVitamin Dmaternal outcomesneonatal outcomesPregnancyvitamin Dvitamin D supplementation

Identifiers

PMID27558700
PMCPMC6056893

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.