ArticleG3 (Bethesda, Md.)2016
Obp56h Modulates Mating Behavior in Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Genetic and behavioral analyses suggest that larval and adult stages of Lucilia cuprina employ different sensory systems to detect rotten beef.Parasites & vectors · 2025Article
- Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025Article
- Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- The vitellogenin receptor gene contributes to mating and host-searching behaviors in parasitoid wasps.iScience · 2023Article
- Pleiotropic fitness effects of a Drosophila odorant-binding protein.G3 (Bethesda, Md.) · 2023Article
- Stochastic Modeling of Gene Expression Evolution Uncovers Tissue- and Sex-Specific Properties of Expression Evolution in theJournal of computational biology : a journal of computational molecular cell biology · 2023Article
- Roles of insect odorant binding proteins in communication and xenobiotic adaptation.Frontiers in insect science · 2023Review
- The 40-Year Mystery of Insect Odorant-Binding Proteins.Biomolecules · 2021Review
- Article
- Behavioral and Transcriptional Response to Selection for Olfactory Behavior inG3 (Bethesda, Md.) · 2020Article
- Mosquitoes cloak their legs to resist insecticides.Proceedings. Biological sciences · 2019Article
- Odorant binding protein 69a connects social interaction to modulation of social responsiveness in Drosophila.PLoS genetics · 2018Article
- Functional Characterization of Odorant Binding Protein 27 (RproOBP27) FromFrontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Social interactions in insects are driven by conspecific chemical signals that are detected via olfactory and gustatory neurons. Odorant binding proteins (Obps) transport volatile odorants to chemosensory receptors, but their effects on behaviors remain poorly characterized. Here, we report that RNAi knockdown of Obp56h gene expression in Drosophila melanogaster enhances mating behavior by reducing courtship latency. The change in mating behavior that results from inhibition of Obp56h expression is accompanied by significant alterations in cuticular hydrocarbon (CHC) composition, including reduction in 5-tricosene (5-T), an inhibitory sex pheromone produced by males that increases copulation latency during courtship. Whole genome RNA sequencing confirms that expression of Obp56h is virtually abolished in Drosophila heads. Inhibition of Obp56h expression also affects expression of other chemoreception genes, including upregulation of lush in both sexes and Obp83ef in females, and reduction in expression of Obp19b and Or19b in males. In addition, several genes associated with lipid metabolism, which underlies the production of cuticular hydrocarbons, show altered transcript abundances. Our data show that modulation of mating behavior through reduction of Obp56h is accompanied by altered cuticular hydrocarbon profiles and implicate 5-T as a possible ligand for Obp56h.
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