ArticleNature communications2016
Long-term time-lapse microscopy of C. elegans post-embryonic development.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- A circadian clock gene homolog regulates developmental timing and male mating circuitry iniScience · 2026Article
- A desynchrony mechanism between events triggers a compensatory delay during Caenorhabditis elegans development.PLoS biology · 2026Article
- Desynchrony between events triggers a compensatory delay duringbioRxiv : the preprint server for biology · 2026Article
- Body-wide synchronization of insulin-signaling dependent DAF-16/FOXO nuclear translocation pulses correlated with C. elegans growth.Nature communications · 2025Article
- Integrated Microfluidic Platform for Longitudinal Imaging, Functional Assays, and Downstream Proteomics in C. elegans.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Video microscopy: an old story with a bright biological future.Biomedical engineering online · 2025Review
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.Nature communications · 2023Article
- A bacterial pathogen induces developmental slowing by high reactive oxygen species and mitochondrial dysfunction in Caenorhabditis elegans.Cell reports · 2023Article
- The rhizodynamics robot: Automated imaging system for studying long-term dynamic root growth.PloS one · 2023Article
- Visualizing and quantifying molecular and cellular processes in Caenorhabditis elegans using light microscopy.Genetics · 2022Review
- Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans.Nature communications · 2022Article
- Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development.BMC biology · 2022Article
- Temporal scaling inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Microfluidic-based imaging of complete Caenorhabditis elegans larval development.Development (Cambridge, England) · 2021Article
- Inferring temporal organization of postembryonic development from high-content behavioral tracking.Developmental biology · 2021Article
- CentTracker: a trainable, machine-learning-based tool for large-scale analyses ofMolecular biology of the cell · 2021Article
- Microfluidic approaches forAnimal cells and systems · 2020Review
- Alignment of Cell Lineage Trees Elucidates Genetic Programs for the Development and Evolution of Cell Types.iScience · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We present a microscopy technique that enables long-term time-lapse microscopy at single-cell resolution in moving and feeding Caenorhabditis elegans larvae. Time-lapse microscopy of C. elegans post-embryonic development is challenging, as larvae are highly motile. Moreover, immobilization generally leads to rapid developmental arrest. Instead, we confine larval movement to microchambers that contain bacteria as food, and use fast image acquisition and image analysis to follow the dynamics of cells inside individual larvae, as they move within each microchamber. This allows us to perform fluorescence microscopy of 10-20 animals in parallel with 20 min time resolution. We demonstrate the power of our approach by analysing the dynamics of cell division, cell migration and gene expression over the full ∼48 h of development from larva to adult. Our approach now makes it possible to study the behaviour of individual cells inside the body of a feeding and growing animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.