ArticleScientific reports2016
Hypomineralized Second Primary Molars as Predictor of Molar Incisor Hypomineralization.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04344340 (The Association Between MIH and HSPM), which is not on this map. Cited by 46 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association Between MIH and HSPM
Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Global prevalence of hypomineralised second primary molars: an updated systematic review with a meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Which diagnostic tools and criteria to use for diagnosis of HSPM and MIH? A systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Pooled it
- Association of hypomineralized second primary molars (HSPM) and hypomineralized primary canines (HPC) with molar-incisor hypomineralization (MIH): a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Association of Molar Incisor Hypomineralization with Hypomineralized Second Primary Molars: An Updated Systematic Review with a Meta-Analysis and Trial Sequential Analysis.Caries research · 2025Pooled it
- The prevalence of molar-incisor hypomineralization: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Knowledge and management of hypomineralisation of second primary molars among Brazilian dentists: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Prevalence and characteristics of hypomineralised second primary molars in Irish school children.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Increasing Diagnosis of Enamel Hypomineralisation in a Sample of More Than 70 000 Children in the City of Zurich: Repeated Cross-Sectional Prevalence Analyses and a Retrospective Longitudinal Cohort Analysis.International journal of paediatric dentistry · 2026Observational
- Prevalence and Associated Factors of Hypomineralised Second Primary Molars in 3-5-Year-Old Children in Aydın, Türkiye.Oral health & preventive dentistry · 2026Article
- Enamel Defects Among Orphanage Children: A Multi-Country Case-Control Study.International dental journal · 2026Article
- Prevalence, clinical characteristics, and associated factors of molar-incisor hypomineralisation among schoolchildren: a cross-sectional study in the Vietnamese Northern provinces.Scientific reports · 2025Article
- Knowledge, and treatment of molar incisor hypomineralisation (MIH) among dentists in Jordan: a cross-sectional questionnaire based study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Article
- Risk for molar incisor hypomineralization in children with hypomineralizations in the deciduous dentition: a case-control study on children from a Swiss suburban region.BMC oral health · 2025Article
- Differential Expression of Hard Tissue Proteins in Hypomineralized Second Primary Molars in Comparison to Normal Teeth.Clinical and experimental dental research · 2025Article
- Hypomineralized primary teeth and their association with Molar Incisor Hypomineralization: a cross-sectional study.Brazilian oral research · 2025Article
- Current Knowledge of the Etiology and Management of Molar Incisor Hypomineralization in Children: A Narrative Review.Cureus · 2024Review
- Awareness of Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPMs) among Northern Italian Dentists: A Questionnaire Survey.Dentistry journal · 2024Article
- Enamel Hypomineralization: Prevalence, Defect Characteristics in Primary Dentition in a Northern Indian Region.International journal of clinical pediatric dentistry · 2024Article
- Dental treatment provided to special needs children under general anesthesia in a tertiary care hospital - A cross sectional retrospective study.The Saudi dental journal · 2024Article
- Dental Developmental Defects: A Pilot Study to Examine the Prevalence and Etiology in a Population of Children between 2 and 15 Years of Age.Dentistry journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molar incisor hypomineralization (MIH) is a developmental defect of dental enamel that shares features with hypomineralized second primary molars (HSPM). Prior to permanent tooth eruption, second primary molars could have predictive value for permanent molar and incisor hypomineralization. To assess this possible relationship, a cross-sectional study was conducted in a sample of 414 children aged 8 and 9 years from the INMA cohort in Valencia (Spain). A calibrated examiner (linear-weighted Kappa 0.83) performed the intraoral examinations at the University of Valencia between November 2013 and 2014, applying the diagnostic criteria for MIH and HSPM adopted by the European Academy of Paediatric Dentistry. 100 children (24.2%) presented MIH and 60 (14.5%) presented HSPM. Co-occurrence of the two defects was observed in 11.1% of the children examined. The positive predictive value was 76.7% (63.9-86.6) and the negative predictive value 84.7% (80.6-88.3). The positive likelihood ratio (S/1-E) was 10.3 (5.9-17.9) and the negative likelihood ratio (1-S/E) 0.57 (0.47-0.68). The odds ratio was 18.2 (9.39-35.48). It was concluded that while the presence of HSPM can be considered a predictor of MIH, indicating the need for monitoring and control, the absence of this defect in primary dentition does not rule out the appearance of MIH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.