ArticleJournal of clinical laboratory analysis2017
Reference Intervals of and Relationships among Essential Trace Elements in Whole Blood of Children Aged 0-14 years.
Article in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Data-driven age partitioning for pediatric serum copper: implications for reference interval interpretation.Practical laboratory medicine · 2026Article
- Comparative analysis reveals distinct metal and inflammatory cytokine profiles in the cerebrospinal fluid of children with neurological disorders.Frontiers in toxicology · 2026Article
- A2 β-casein infant formula with high sn-2 palmitate and casein phosphopeptides (CPP) supports energy and mineral absorption in Chinese infants.Frontiers in nutrition · 2026Article
- Perturbations of Zinc Homeostasis and Onset of Neuropsychiatric Disorders.International journal of molecular sciences · 2025Review
- Observational
- Determination of 11 minerals in children using inductively coupled plasma mass spectrometry.BMC pediatrics · 2021Article
- Method for Determining Regional Reference Values of Metal Content in Biological Substrates and Their Intake into the Body via Drinking Water.International journal of environmental research and public health · 2021Article
- Establishment and Verification of Sex- and Age-Specific Serum Electrolyte Reference Intervals in Healthy Han Children in Changchun, Northeastern China.BioMed research international · 2019Article
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7 authors.
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Abstract
backgroundEssential trace elements are vital to human health. In this study, our aim was to establish reference intervals of and to evaluate relationships among Ca, Fe, Cu, Mg, and Zn for children.
methodsWe collected blood samples of 3210 children aged 0-14 years from Lu'an, China, and concentrations of the above elements were determined by atomizer absorption spectrophotometer. A nonparametric method was used to establish the reference intervals.
resultsGender-related differences in concentrations were not statistically significant for the elements, except for Fe. There were strong positive and negative correlations between age and Fe (R = 0.305, P < 0.001), Zn (R = 0.573, P < 0.001); and age and Ca (R = -0.372, P < 0.001), Cu (R = -0.127, P < 0.001), respectively. Correlations between Ca-Mg (r = 0.222~0.384, P < 0.001), Fe-Mg (r = 0.495~0.614, P < 0.001), and Fe-Zn (r = 0.239~0.471, P < 0.001) were the strongest compared with others. In multivariable linear regression, after adjusted for confounding factors, the associations between Zn-Fe and Mg-Fe were the strongest with per concentration quintile increase of Fe caused Zn and Mg increasing by 4.19% (β = 0.041; 95% CI: 0.037, 0.045; P < 0.001) and 3.87% (β = 0.038; 95% CI: 0.036, 0.040; P < 0.001), respectively.
conclusionsGender- and age-based reference intervals of Ca, Fe, Cu, Mg, and Zn for children were established, and correlations between them were quite complex. More works are needed to illuminate these relationships and their impacts on children's health.
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