ArticleObesity (Silver Spring, Md.)2016
Diet-induced obese mice exhibit altered immune responses to acute lung injury induced by Escherichia coli.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Obesity promotes urinary tract infection by disrupting bladder focal adhesion kinase signaling.iScience · 2025Article
- Diabetes Mellitus, Energy Metabolism, and COVID-19.Endocrine reviews · 2024Review
- A role of STING signaling in obesity-induced lung inflammation.International journal of obesity (2005) · 2023Article
- Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction.Respiratory research · 2023Article
- Obesity Paradox in Lung Diseases: What Explains It?Obesity facts · 2023Review
- More Active Intestinal Immunity Developed by Obese Mice Than Non-Obese Mice After Challenged byFrontiers in veterinary science · 2022Article
- The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections.International journal of molecular sciences · 2021Review
- Effect of intranasal instillation of Escherichia coli on apoptosis of spleen cells in diet-induced-obese mice.Scientific reports · 2020Article
- Obesity Enhances Antioxidant Capacity and Reduces Cytokine Levels of the Spleen in Mice to Resist Splenic Injury Challenged byJournal of immunology research · 2020Article
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- Delayed Pulmonary Apoptosis of Diet-Induced Obesity Mice followingOxidative medicine and cellular longevity · 2019Article
- Site-Specific Reprogramming of Macrophage Responsiveness to Bacterial Lipopolysaccharide in Obesity.Frontiers in immunology · 2019Article
- AMPKα pathway involved in hepatic triglyceride metabolism disorder in diet-induced obesity mice followingAging · 2018Article
- Histopathological Changes Caused by Inflammation and Oxidative Stress in Diet-Induced-Obese Mouse following Experimental Lung Injury.Scientific reports · 2018Article
- Timing of valproic acid in acute lung injury: prevention is the best therapy?The Journal of surgical research · 2017Article
- High-Fat Feeding Protects Mice From Ventilator-Induced Lung Injury, Via Neutrophil-Independent Mechanisms.Critical care medicine · 2017Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveObesity has been associated with impaired immunity and increased susceptibility to bacterial infection. It also exerts protective effects against mortality secondary to acute lung injury. The effects of obesity on immune responses to acute lung injury induced by Escherichia coli were investigated to determine if the above-mentioned differences in its effects were related to infection severity.
methodsDiet-induced obesity (DIO) and lean control mice received intranasal instillations of 10(9) or 10(10) CFUs of E. coli. The immune responses were examined at 0 h (uninfected), 24 h, and 96 h postinfection.
resultsFollowing infection, the DIO mice exhibited higher leukocyte, interleukin (IL)-10, IL-6, and tumor necrosis factor-α levels and more severe lung injury than the lean mice. Following inoculation with 10(10) CFUs of E. coli, the DIO mice exhibited higher mortality and more severe inflammation-induced injury than the lean mice, but no differences in E. coli counts were noted between the two groups. However, inoculated with 10(9) CFUs of E. coli, the DIO mice exhibited smaller E. coli burdens at 24 h and 96 h after infection, as well as lower concentrations of IL-10 and tumor necrosis factor-α and less severe lung injury at 96 h after infection.
conclusionsThe results support the emerging view that obesity may be beneficial in the setting of milder infection but detrimental in the setting of more severe infection.
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