ArticleScientific reports2016
Energy metabolism in intestinal epithelial cells during maturation along the crypt-villus axis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 85 citations in OpenAlex.
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- Modifying microbially derived short chain fatty acids to promote health.The Journal of physiology · 2026Review
- Maternal High-Fat Diet Worsens Necrotizing Enterocolitis via Effects on Mitochondrial Function in Newborn Mice.Cellular and molecular gastroenterology and hepatology · 2026Article
- Alcohol-induced gut permeability defect through dysbiosis and enterocytic mitochondrial interference causing pro-inflammatory macrophages in a dose dependent manner.Scientific reports · 2025Article
- Maternal Roughage Sources Influence the Gastrointestinal Development of Goat Kids by Modulating the Colonization of Gastrointestinal Microbiota.Animals : an open access journal from MDPI · 2025Article
- Effect of a trub, hops, and yeast mixture on jejunal mucosal immune status, oxidative stress status, structure, and growth performance of nursery pigs.Journal of animal science · 2025Article
- Impact of different feed intake levels on intestinal morphology and epithelial cell differentiation in piglets.Journal of animal science · 2025Article
- Vitamin B5 supplementation enhances intestinal development and alters microbes in weaned piglets.Animal biotechnology · 2024Article
- Azathioprine promotes intestinal epithelial cell differentiation into Paneth cells and alleviates ileal Crohn's disease severity.Scientific reports · 2024Article
- Dietary xylo-oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens.Journal of animal science and biotechnology · 2024Article
- High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Modulation of colonic immunometabolic responses during Clostridioides difficile infection ameliorates disease severity and inflammation.Scientific reports · 2023Article
- Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice.Nutrients · 2023Article
- Exercise improves homeostasis of the intestinal epithelium by activation of apelin receptor-AMP-activated protein kinase signalling.The Journal of physiology · 2023Article
- Abundance of Amino Acid Transporters and mTOR Pathway Components in the Gastrointestinal Tract of Lactating Holstein Cows.Animals : an open access journal from MDPI · 2023Article
- Spatial transcriptomics add a new dimension to our understanding of the gut.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Dietary butyrate, lauric acid and stearic acid improve gut morphology and epithelial cell turnover in weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Article
- Intestinal plasticity and metabolism as regulators of organismal energy homeostasis.Nature metabolism · 2022Review
- Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues.NPJ Regenerative medicine · 2022Review
- Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels.Molecular systems biology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal epithelial cells continuously migrate and mature along crypt-villus axis (CVA), while the changes in energy metabolism during maturation are unclear in neonates. The present study was conducted to test the hypothesis that the energy metabolism in intestinal epithelial cells would be changed during maturation along CVA in neonates. Eight 21-day-old suckling piglets were used. Intestinal epithelial cells were isolated sequentially along CVA, and proteomics was used to analyze the changes in proteins expression in epithelial cells along CVA. The identified differentially expressed proteins were mainly involved in cellular process, metabolic process, biological regulation, pigmentation, multicellular organizational process and so on. The energy metabolism in intestinal epithelial cells of piglets was increased from the bottom of crypt to the top of villi. Moreover, the expression of proteins related to the metabolism of glucose, most of amino acids, and fatty acids was increased in intestinal epithelial cells during maturation along CVA, while the expression of proteins related to glutamine metabolism was decreased from crypt to villus tip. The expression of proteins involved in citrate cycle was also increased intestinal epithelial cells during maturation along CVA. Moreover, dietary supplementation with different energy sources had different effects on intestinal structure of weaned piglets.
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