Trial reportJournal of clinical microbiology2016
Chlorhexidine and Mupirocin Susceptibility of Methicillin-Resistant Staphylococcus aureus Isolates in the REDUCE-MRSA Trial.
Trial report in Journal of clinical microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00980980 (Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal), which is not on this map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 94 citations in OpenAlex.
- [Effect of 2% Chlorhexidine Bathing on the Incidence of Hospital-Acquired Infection and Multidrug-Resistant Organisms in Adult Intensive Care Unit Patients: Systematic Review and Meta-Analysis].Journal of Korean Academy of Nursing · 2021Pooled it
- Chlorhexidine bathing of the critically ill for the prevention of hospital-acquired infection.The Cochrane database of systematic reviews · 2019Pooled it
- Evidence for the effectiveness of chlorhexidine bathing and health care-associated infections among adult intensive care patients: a trial sequential meta-analysis.BMC infectious diseases · 2018Pooled it
- Mupirocin-resistantAntimicrobial resistance and infection control · 2018Pooled it
- Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Trial
- Trial
- Decolonization to Reduce Postdischarge Infection Risk among MRSA Carriers.The New England journal of medicine · 2019Trial
- Increase in imported mupirocin-resistantNew microbes and new infections · 2026Article
- Antimicrobial Activity of Natural Extracts Against Catheter-Colonizing Methicillin-ResistantBiomedicines · 2025Article
- Distribution ofFrontiers in cellular and infection microbiology · 2025Article
- Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) harboring mupirocin and biocide resistance genes in a large health care system.American journal of infection control · 2025Article
- Antiseptic susceptibility profiles of canine pyoderma-associated staphylococci in Japan: first identification of plasmid-borneFrontiers in veterinary science · 2025Article
- Staphylococcus aureus screening and preoperative decolonisation with Mupirocin and Chlorhexidine to reduce the risk of surgical site infections in orthopaedic surgery: a pre-post study.Antimicrobial resistance and infection control · 2024Article
- Impact of Povidone Application to Nares in Addition to Chlorhexidine Bath in Critically Ill Patients on Nosocomial Bacteremia and Central Line Blood Stream Infection.Journal of clinical medicine · 2024Article
- Bayesian modeling of the impact of antibiotic resistance on the efficiency of MRSA decolonization.PLoS computational biology · 2023Article
- Impact of measurement and feedback on chlorhexidine gluconate bathing among intensive care unit patients: A multicenter study.Infection control and hospital epidemiology · 2023Article
- Development of a Broth Microdilution Method To Characterize Chlorhexidine MICs among Bacteria Collected from 2005 to 2019 at Three U.S. Sites.Microbiology spectrum · 2023Article
- A tale of two intensive care units (ICUs): BaselineInfection control and hospital epidemiology · 2023Article
- Effective decolonization strategy for mupirocin-resistantMaterials today. Bio · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 1 country.
Funding
Abstract
Whether targeted or universal decolonization strategies for the control of methicillin-resistant Staphylococcus aureus (MRSA) select for resistance to decolonizing agents is unresolved. The REDUCE-MRSA trial (ClinicalTrials registration no. NCT00980980) provided an opportunity to investigate this question. REDUCE-MRSA was a 3-arm, cluster-randomized trial of either screening and isolation without decolonization, targeted decolonization with chlorhexidine and mupirocin, or universal decolonization without screening to prevent MRSA infection in intensive-care unit (ICU) patients. Isolates from the baseline and intervention periods were collected and tested for susceptibility to chlorhexidine gluconate (CHG) by microtiter dilution; mupirocin susceptibility was tested by Etest. The presence of the qacA or qacB gene was determined by PCR and DNA sequence analysis. A total of 3,173 isolates were analyzed; 2 were nonsusceptible to CHG (MICs, 8 μg/ml), and 5/814 (0.6%) carried qacA or qacB At baseline, 7.1% of MRSA isolates expressed low-level mupirocin resistance, and 7.5% expressed high-level mupirocin resistance. In a mixed-effects generalized logistic regression model, the odds of mupirocin resistance among clinical MRSA isolates or MRSA isolates acquired in an ICU in intervention versus baseline periods did not differ across arms, although estimates were imprecise due to small numbers. Reduced susceptibility to chlorhexidine and carriage of qacA or qacB were rare among MRSA isolates in the REDUCE-MRSA trial. The odds of mupirocin resistance were no different in the intervention versus baseline periods across arms, but the confidence limits were broad, and the results should be interpreted with caution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.