Evidence map›Paper›PMID 27558158›Full record

ArticleAmerican journal of physiology. Cell physiology2016

Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation.

Angela C Gomez, Timothy W Holford, Naohiro Yamaguchi

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Characterization of cardiac disease-associated mutations in RyR2 CaAmerican journal of physiology. Cell physiology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Interplay between MgNature communications · 2024
    Article
  6. Review
  7. Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. CaeLife · 2022
    Article
  9. Regulatory mechanisms of ryanodine receptor/CaJournal of muscle research and cell motility · 2021
    Review
  10. Fitness Costs of Chlorantraniliprole Resistance Related to theInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. RYR1 causing distal myopathy.Molecular genetics & genomic medicine · 2017
    Article
  15. Structures of the colossal RyR1 calcium release channel.Current opinion in structural biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Angela C GomezDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina; and.
Timothy W HolfordDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina; and.
Naohiro YamaguchiDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina; and yamaguch@musc.edu.
Medical University of South Carolina · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
Isoform-Specific Regulation of Skeletal Muscle Calcium Channel by CalmodulinR03AR061030 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAMAGUCHI, NAOHIRO · 2011 to 2013
$218k
NCATS NIH HHS UL1 TR001450NIAMS NIH HHS R03 AR061030
6 · The paper itself

Abstract

Channel activities of skeletal muscle ryanodine receptor (RyR1) are activated by micromolar Ca

Indexed as

Amino Acid SequenceCalciumCell LineCytoplasmHEK293 CellsHumansIon TransportMagnesiumMalignant HyperthermiaMuscle, SkeletalMutationProtein BindingProtein IsoformsRyanodine Receptor Calcium Release ChannelCalciumMagnesiumProtein IsoformsRyanodine Receptor Calcium Release ChannelCa2+-dependent inactivationcentral core diseasecentronuclear myopathymalignant hyperthermiatype-1 ryanodine receptor

Identifiers

PMID27558158
PMCPMC5130589
OpenAlexW2517918221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.