Evidence map›Paper›PMID 27557978›Full record

ArticleNeurotoxicity research2016

Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.

Natalia Kasica, Piotr Podlasz, Maria Sundvik, Andrea Tamas, Dora Reglodi, Jerzy Kaleczyc

Open access · hybridAbstract read
In one paragraph

Article in Neurotoxicity research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Natalia KasicaDepartment of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, box 105J, 10-719, Olsztyn, Poland. natalia_kasica@wp.pl.ORCID 0000-0002-0242-2587
Piotr PodlaszDepartment of Pathophysiology, Forensic Veterinary and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-719, Olsztyn, Poland.
Maria SundvikDepartment of Anatomy, Neuroscience Center, University of Helsinki, Haartmaninkatu 8 (Biomedicum Helsinki), 00290, Helsinki, Finland.
Andrea TamasDepartment of Anatomy, University of Pecs, Szigeti 12, 7624, Pecs, Hungary.
Dora ReglodiDepartment of Anatomy, University of Pecs, Szigeti 12, 7624, Pecs, Hungary.
Jerzy KaleczycDepartment of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, box 105J, 10-719, Olsztyn, Poland.
University of Warmia and Mazury in Olsztyn · PLUniversity of Pecs · HUUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide, with known antiapoptotic functions. Our previous in vitro study has demonstrated the ameliorative role of PACAP-38 in chicken hair cells under oxidative stress conditions, but its effects on living hair cells is now yet known. Therefore, the aim of the present study was to investigate in vivo the protective role of PACAP-38 in hair cells found in zebrafish (Danio rerio) sense organs-neuromasts. To induce oxidative stress the 5-day postfertilization (dpf) zebrafish larvae were exposed to 1.5 mM H

Indexed as

AnimalsAntioxidantsApoptosisCaspase 3HumansHydrogen PeroxideImmunohistochemistryMicroscopy, ConfocalModels, AnimalMotor ActivityNeuroprotectionNeuroprotective AgentsOxidative Stressp38 Mitogen-Activated Protein KinasesPituitary Adenylate Cyclase-Activating PolypeptideRandom AllocationAntioxidantsCaspase 3Hydrogen PeroxideNeuroprotective Agentsp38 Mitogen-Activated Protein KinasesPituitary Adenylate Cyclase-Activating PolypeptideAntioxidantApoptosisBehaviorHydrogen peroxideNeuromastPACAP

Identifiers

PMID27557978
PMCPMC5047952
OpenAlexW2514020225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.