Evidence map›Paper›PMID 27557777›Full record

ArticleJournal of neurovirology2017

Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining "symptomatic" versus "asymptomatic" HAND.

Lisa C Obermeit, Jessica Beltran, Kaitlin B Casaletto, Donald R Franklin, Scott Letendre, Ronald Ellis, Christine Fennema-Notestine, Florin Vaida, Ann C Collier, Christina M Marra and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  16. Review
  17. HIV-associated neurocognitive disorder.Current opinion in infectious diseases · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Lisa C ObermeitDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Jessica BeltranDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Kaitlin B CasalettoSDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Donald R FranklinDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Scott LetendreDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Ronald EllisDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Christine Fennema-NotestineDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Florin VaidaDepartment of Family Medicine & Public Health, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Ann C CollierDepartment of Medicine, Harborview Medical Center, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.
Christina M MarraDepartment of Neurology, University of Washington, Seattle, WA, USA.
David CliffordDepartment of Neurology, Washington University in St. Louis, 660 South Euclid Avenue, Saint Louis, MO, 63110, USA.
Benjamin GelmanDepartment of Pathology, University of Texas Medical Branch, 3.118 Keiler Building, 301 University Boulevard, Galveston, TX, 77555-0609, USA.
Ned SacktorDepartment of Neurology, Johns Hopkins University, 600 North Wolfe Street, Sheikh Zayed Tower, Baltimore, MD, 21287, USA.
Susan MorgelloDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, 21287, USA.
David SimpsonDepartment of Neurology, Icahn School of Medicine at Mount Sinai, 1428 Madison Avenue, New York, NY, 21287, USA.
J Allen McCutchanDepartment of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Igor GrantDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA.
Robert K HeatonDepartment of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA. rheaton@ucsd.edu.
CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) Group
University of California, San Diego · USIcahn School of Medicine at Mount Sinai · USSan Diego State University · USUniversity of Washington · USJohns Hopkins University · USThe University of Texas Medical Branch at Galveston · USWashington University in St. Louis · US

Funding

Leadership and Operations Center (LOC), AIDS Clinical Trials Group (ACTG); LOC 1/UM1AI068636 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, RAJESH T GANDHI · 2011 to 2026
$1073.1M
AIDS Clinical Trials Group NetworkU01AI068636 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI KURITZKES, DANIEL R. · 2006 to 2010
$147.1M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Latesha Ellen Elopre · 1988 to 2026
$84.1M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello · 2001 to 2026
$50.4M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
Therapeutic CoreP30MH075673 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Barbara Stauch Slusher · 2006 to 2026
$33.2M
PEPFAR Assistance Program for the Ethiopian Uniformed ServicesU2GPS000623 · PS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCUTCHAN, JOHN ALLEN · 2006 to 2010
$29.0M
YOGA FOR THE MANAGEMENT OF HIV-METABOLIC SYNDROMESM01RR000036 · NCRR · WASHINGTON UNIVERSITY · PI REEDS, DOMINIC N · 1985 to 2007
$25.4M
Seattle Vaccine Trials UnitUM1AI069481 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Rachel Ann Bender Ignacio, Margaret Juliana McElrath · 2012 to 2026
$24.4M
NCATS NIH HHS UL1 TR000067NCATS NIH HHS UL1 TR000448NCHHSTP CDC HHS U2G PS000623NCRR NIH HHS K30 RR022681NCRR NIH HHS M01 RR000036NHLBI NIH HHS R56 HL129881NIAID NIH HHS P01 AI057005NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI047033NIAID NIH HHS R01 AI111806NIAID NIH HHS R01 AI125026NIAID NIH HHS R43 AI068543NIAID NIH HHS R44 AI068543NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI068636NIAID NIH HHS U01 AI069432NIAID NIH HHS U01 AI069481NIAID NIH HHS U01 AI069495NIAID NIH HHS U01 AI074521NIAID NIH HHS UM1 AI068636NIAID NIH HHS UM1 AI069481NIAID NIH HHS UM1 AI069495NIAID NIH HHS UM1 AI120176NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG034852NIA NIH HHS R01 AG042165NIA NIH HHS R01 AG048650NIA NIH HHS RF1 AG015301NIDA NIH HHS DP1 DA037979NIDA NIH HHS F31 DA035708NIDA NIH HHS P50 DA026306NIDA NIH HHS R01 DA036165NIDA NIH HHS R01 DA037611NIDA NIH HHS R01 DA039775NIDA NIH HHS R21 DA037667NIDA NIH HHS T32 DA031098NIDDK NIH HHS R21 DK105917NIMH NIH HHS HHSN271201000027CNIMH NIH HHS HHSN271201000030CNIMH NIH HHS HHSN271201000036CNIMH NIH HHS N01 MH022005NIMH NIH HHS P30 MH062512NIMH NIH HHS P30 MH075673NIMH NIH HHS R01 MH058076NIMH NIH HHS R01 MH060720NIMH NIH HHS R01 MH078737NIMH NIH HHS R01 MH080150NIMH NIH HHS R01 MH083552NIMH NIH HHS R01 MH084796NIMH NIH HHS R01 MH085608NIMH NIH HHS R01 MH092225NIMH NIH HHS R01 MH094159NIMH NIH HHS R01 MH095621NIMH NIH HHS R01 MH099733NIMH NIH HHS R01 MH101017NIMH NIH HHS R01 MH104134NIMH NIH HHS R01 MH107345NIMH NIH HHS R03 MH103995NIMH NIH HHS R25 MH080663NIMH NIH HHS U01 MH083501NIMH NIH HHS U01 MH083506NIMH NIH HHS U13 MH081676NIMH NIH HHS U24 MH100931NINDS NIH HHS R01 NS034235NINDS NIH HHS R01 NS072005NINDS NIH HHS R01 NS079166NINDS NIH HHS R01 NS080655NINDS NIH HHS R01 NS081196NINDS NIH HHS R01 NS082120NINDS NIH HHS U01 NS032228NINDS NIH HHS U10 NS077384NINR NIH HHS R01 NR012657NINR NIH HHS R01 NR012907NINR NIH HHS R01 NR014449NINR NIH HHS R21 NR015009
6 · The paper itself

Abstract

The criteria for differentiating symptomatic from asymptomatic HIV-associated neurocognitive disorder require evaluation of (1) cognitive impairment, (2) daily functioning declines, and (3) whether the functional declines are attributable to cognitive versus physical problems. Many providers rely only on self-report to evaluate these latter criteria. However, the accuracy of patient-provided information may be limited. This study evaluated the validity of self-assessment for HIV-associated neurocognitive disorder (HAND) diagnoses by comparing objective findings with self-report of criteria 2 and 3 above. Self-reports were used to stratify 277 cognitively impaired HIV+ individuals into functionally dependent (n = 159) and independent (n = 118) groups, followed by group comparisons of objective functional problems. The dependent group was then divided into those who self-attributed their functional dependence to only cognitive (n = 80) versus only physical (n = 79) causes, for further comparisons on objective findings. The functionally dependent group was significantly worse than the independent group on all objective disability characteristics except severity of cognitive impairment, while those who attributed their dependence to physical (versus cognitive) factors were similar on all objective physical, cognitive, and functioning variables. Of note, 28 % of physical attributors showed no physical abnormalities on neuromedical examinations. Results suggest that patient report is consistently associated with objective measures of functional loss; in contrast, patient identification of physical versus cognitive causes is poorly associated with objective criteria. These findings caution against relying solely on patient self-report to determine whether functional disability in cognitively impaired HIV+ individuals can be attributed to strictly physical causes.

Indexed as

Self ReportActivities of Daily LivingAdultAsymptomatic DiseasesCognitionCognitive DysfunctionFemaleHIV InfectionsHumansMaleMiddle AgedPersons with DisabilitiesPsychiatric Status Rating ScalesSeverity of Illness IndexActivities of daily livingAIDSCognitive disordersEtiologySelf-assessment

Identifiers

PMID27557777
PMCPMC5325815
OpenAlexW2508812043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.