Evidence map›Paper›PMID 27557663›Full record

ArticleThe Journal of biological chemistry2016

Type I γ Phosphatidylinositol Phosphate 5-Kinase i5 Controls the Ubiquitination and Degradation of the Tumor Suppressor Mitogen-inducible Gene 6.

Ming Sun, Jinyang Cai, Richard A Anderson, Yue Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Unraveling the Potential Role of NEDD4-like E3 Ligases in Cancer.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Review
  7. Control of Rab7a activity and localization through endosomal type Igamma PIP 5-kinase is required for endosome maturation and lysosome function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  8. Phosphatidylinositol 4,5-bisphosphate in the Control of Membrane Trafficking.International journal of biological sciences · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ming SunFrom the Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and.
Jinyang CaiFrom the Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and.
Richard A Andersonthe Molecular and Cellular Pharmacology Program, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin 53706.
Yue SunFrom the Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298 and ysun4@vcu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitogen-inducible gene 6 (Mig6) is a tumor suppressor, and the disruption of Mig6 expression is associated with cancer development. Mig6 directly interacts with epidermal growth factor receptor (EGFR) to suppress the activation and downstream signaling of EGFR. Therefore, loss of Mig6 enhances EGFR-mediated signaling and promotes EGFR-dependent carcinogenesis. The molecular mechanism modulating Mig6 expression in cancer remains unclear. Here we demonstrate that type I γ phosphatidylinositol phosphate 5-kinase i5 (PIPKIγi5), an enzyme producing phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P

Indexed as

ProteolysisAdaptor Proteins, Signal TransducingCell Line, TumorEndosomal Sorting Complexes Required for TransportErbB ReceptorsFemaleHumansNedd4 Ubiquitin Protein LigasesPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)Protein DomainsSignal TransductionTumor Suppressor ProteinsUbiquitinationUbiquitin-Protein Ligases1-phosphatidylinositol-4-phosphate 5-kinaseAdaptor Proteins, Signal TransducingEGFR protein, humanEndosomal Sorting Complexes Required for TransportErbB ReceptorsERRFI1 protein, humanNedd4 protein, humanNedd4 Ubiquitin Protein LigasesPhosphatidylinositol 4,5-DiphosphatePhosphotransferases (Alcohol Group Acceptor)Tumor Suppressor ProteinsUbiquitin-Protein Ligasescell signalingE3 ubiquitin ligaseepidermal growth factor receptor (EGFR)Mig6NEDD4-1phosphatidylinositol phosphatasePIPKIγi5tumor suppressorubiquitylation (ubiquitination)

Identifiers

PMID27557663
PMCPMC5076818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.