Evidence map›Paper›PMID 27556947›Full record

ArticleNature2016

Structural basis for inhibition of a voltage-gated Ca

Lin Tang, Tamer M Gamal El-Din, Teresa M Swanson, David C Pryde, Todd Scheuer, Ning Zheng, William A Catterall

Open access · greenAbstract read
In one paragraph

Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 207 citations in OpenAlex.

  1. An Unbiased Drug Screen in a Drosophila Model ofInternational journal of molecular sciences · 2026
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  8. Repurposing 1,4-Dihydropyridine Scaffold: 4-Imidazo[2,1-Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  9. Article
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  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by small-molecule ligands.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lin TangDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
Teresa M SwansonDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
David C PrydeCuradev Pharma, Discovery Park, Sandwich, Kent CT14 9FF, UK.
Todd ScheuerDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA.
University of Washington · USSeattle University · USPfizer (United Kingdom) · GB

Funding

TRAINING IN MOLECULAR BIOPHYSICST32GM008268 · NIGMS · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M, ZHENG, NING · 1988 to 2023
$8.6M
Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE CHANNELSR01NS022625 · NINDS · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1985 to 2019
$6.2M
Structural Basis for Calcium Selectivity and Drug Block of Cav ChannelsR01HL117896 · NHLBI · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A, ZHENG, NING · 2014 to 2017
$1.5M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL112808NHLBI NIH HHS R01 HL117896NIGMS NIH HHS T32 GM008268NINDS NIH HHS R01 NS022625NINDS NIH HHS R01 NS26254
6 · The paper itself

Abstract

Ca

Indexed as

Allosteric RegulationAminesAmlodipineAnimalsBacterial ProteinsBinding SitesCalciumCalcium Channel BlockersCalcium ChannelsCell LineCrystallography, X-RayDihydropyridinesLipidsModels, MolecularMothsMutationAminesAmlodipineBacterial ProteinsCalciumCalcium Channel BlockersCalcium ChannelsDihydropyridinesLipidsNiacinProtein SubunitsUK-59811Verapamil

Identifiers

PMID27556947
PMCPMC5161592
OpenAlexW2508657279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.