ArticleNature2016
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 275 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 1 pooled it
22.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
275 citing papers in PubMed, 1 synthesis or guideline pooled it, 456 citations in OpenAlex.
- Risk of Suicidal Behaviors and Antidepressant Exposure Among Children and Adolescents: A Meta-Analysis of Observational Studies.Frontiers in psychiatry · 2022Pooled it
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Post-traumatic stress disorder: pathogenesis, epidemiological characteristics, animal models, and potential therapeutic strategies.Military Medical Research · 2026Review
- Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Corticotropin-releasing hormone neurons in the bed nucleus of the stria terminalis control wakefulness in physiological and stressful conditions in mice.Molecular psychiatry · 2026Article
- Regulation of amygdala and dopamine system in naïve and chronic alcohol states.Alcohol (Fayetteville, N.Y.) · 2026Article
- Behavioral impact of chemogenetic manipulations of 5-HT DRN neurons in transgenic Tph2-iCre rats.Psychopharmacology · 2026Article
- LC-MS/MS Method for Quantifying the Alterations of Four Neurotransmitters in Plasma From Insomnia Patients Treated With Zhibai Anshen Oral Liquid.Biomedical chromatography : BMC · 2026Article
- The sleep-wake cycle: molecular mechanisms, disorders, and therapeutic targets in the context of energy metabolism.Signal transduction and targeted therapy · 2026Review
- VlPAG/DRN Microglia Drive Neuropathic Pain-Induced Depression via a Defined Neuroimmune Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state.eLife · 2026Article
- Mice produce interneurons in the septum as a response to aversive experiences and antidepressant treatment.Science advances · 2026Article
- The Role of Serotonergic System in Parkinson's Disease-Related Pain.Neuroscience bulletin · 2026Review
- Gut Microbiota and Metabolite Remodeling Underlies the Anxiolytic Effect ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Effects of Physical Exercise on Anxiety and Depression of People with Fibromyalgia: Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of functional morphology and kinesiology · 2026Review
- Gut microbiota-tryptophan-serotonin axis drives anxiety-like behavior via NLRP3-mediated neuronal pyroptosis in the medial prefrontal cortex.Apoptosis : an international journal on programmed cell death · 2026Article
- A discrete serotonergic circuit involved in the generation of tinnitus behavior.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Epigenetic Repression of the Serotonergic Neuron Phenotype Following Adolescent Binge Drinking Is Restored through Inhibition of Proinflammatory Signaling by Exercise and Glycyrrhizic Acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
215 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 5 institutions in 2 countries.
Catherine A Marcinkiewcz *Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Christopher M Mazzone *Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Giuseppe D'AgostinoRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Lindsay R HalladayNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852-9411, USA.
J Andrew HardawayBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jeffrey F DiBertoBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Montserrat NavarroDepartment of Psychology & Neuroscience, College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Nathan BurnhamDepartment of Psychology & Neuroscience, College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Claudia CristianoRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Cayce E DorrierBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gregory J TiptonBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Charu RamakrishnanDepartment of Bioengineering, Stanford University, Stanford CA 94305, USA.
Tamas KoziczHayward Genetics Center, Tulane University, New Orleans, LA 70112, USA.
Karl DeisserothDepartment of Bioengineering, Stanford University, Stanford CA 94305, USA.
Todd E ThieleBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Zoe A McElligottBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Andrew HolmesNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852-9411, USA.
Lora K HeislerRowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Thomas L KashBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USUniversity of Aberdeen · GBNational Institute on Alcohol Abuse and Alcoholism · USStanford University · USTulane University · US
Funding
UNC ARC Information/Dissemination CoreP60AA011605 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A Herman · 2003 to 2026
$46.3MMouse models of stress disorders and addictionZIAAA000411 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HOLMES, ANDREW · 2009 to 2025
$37.7MThe Role of Serotonin in Alcohol-Withdrawal Induced AnxietyR01AA019454 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Thomas L. Kash · 2010 to 2026
$5.6MMOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISMP50AA011605 · NIAAA · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI LEMASTERS, JOHN J · 1998 to 2002
$4.9MPostdoctoral Research Training in Eating DisordersT32MH076694 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2007 to 2016
$1.8MDeconstructing the role of central nucleus of the amygdala neurotensin neurons in alcohol reward and intoxicationK01AA023555 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MCELLIGOTT, ZOE ANASTASIA · 2015 to 2019
$675k5HT2c-CRF interactions in the BNST: Relevance to anxiety and alcoholF32AA021319 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MARCINKIEWCZ, CATHERINE ANNE · 2013 to 2014
$107kAlcohol Modulation of a Novel Local BNST CircuitF31AA023440 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAZZONE, CHRISTOPHER · 2015 to 2016
$60kNIAAA NIH HHS F31 AA023440NIAAA NIH HHS F32 AA021319NIAAA NIH HHS K01 AA023555NIAAA NIH HHS P50 AA011605NIAAA NIH HHS P60 AA011605NIAAA NIH HHS R01 AA019454NIMH NIH HHS T32 MH076694Wellcome Trust 098012
Abstract
Serotonin (also known as 5-hydroxytryptamine (5-HT)) is a neurotransmitter that has an essential role in the regulation of emotion. However, the precise circuits have not yet been defined through which aversive states are orchestrated by 5-HT. Here we show that 5-HT from the dorsal raphe nucleus (5-HT
Indexed as
AmygdalaAnimalsAnxietyAnxiety DisordersCorticotropin-Releasing HormoneCRF Receptor, Type 1Dorsal Raphe NucleusFearFemaleFluoxetineHypothalamusMaleMiceNeuronsOptogeneticsReceptors, Corticotropin-Releasing HormoneCorticotropin-Releasing HormoneCRF Receptor, Type 1FluoxetineReceptors, Corticotropin-Releasing HormoneSelective Serotonin Reuptake InhibitorsSerotonin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.