ReviewPlastic and reconstructive surgery2016
An Update on the Appropriate Role for Hyperbaric Oxygen: Indications and Evidence.
Review in Plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Efficacy of Hyperbaric Oxygen Therapy as an Adjunct in Aesthetic Surgery: A Systematic Review and Meta-analysis of Postoperative Outcomes and Complications.Aesthetic plastic surgery · 2025Pooled it
- Hyperbaric oxygen therapy for radiation enteritis and clinical parameters: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Combination of Hyperbaric Oxygen Therapy and Oral Steroids for the Treatment of Sudden Sensorineural Hearing Loss: Early or Late?Medicina (Kaunas, Lithuania) · 2022Trial
- The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.Aging · 2021Trial
- Facial Reconstruction: The Nuances of Managing Undesirable Results.Seminars in plastic surgery · 2024Review
- Quality of evidence supporting the role of hyperbaric oxygen therapy for diabetic foot ulcers.International wound journal · 2024Review
- Global outcomes and lessons learned in the management of Fournier's gangrene from high-volume centres: findings from a literature review over the last two decades.World journal of urology · 2022Review
- Hyperbaric Oxygen Improves the Survival and Angiogenesis of Fat Grafts after Autologous Fat Transplantation.BioMed research international · 2022Article
- The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length-The difference between zero and one: A case report.Frontiers in neurology · 2022Article
- Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.Aging · 2021Article
- A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities.Medicina (Kaunas, Lithuania) · 2021Review
- Results of hyperbaric oxygen treatment in an at-risk nasal flap following trauma.Diving and hyperbaric medicine · 2021Article
- Thermal Effects of Topical Hyperbaric Oxygen Therapy in Hard-to-Heal Wounds-A Pilot Study.International journal of environmental research and public health · 2021Article
- Update on hyperbaric oxygen therapy in burn treatment.Wiener klinische Wochenschrift · 2021Review
- Integrative Role of Hyperbaric Oxygen Therapy on Healthspan, Age-Related Vascular Cognitive Impairment, and Dementia.Frontiers in aging · 2021Review
- Article
- Hyperbaric Oxygen Therapy: Descriptive Review of the Technology and Current Application in Chronic Wounds.Plastic and reconstructive surgery. Global open · 2020Review
- Hyperbaric oxygen in animal model of rheumatoid arthritis: Analysis Of HIF-1α, ACPA and IL-17a.Infectious disease reports · 2020Article
- Study of the Effect of Hyperbaric Oxygen Therapy on the Viability of Dorsal Cutaneous Flaps in Tobacco-Exposed Rats.Aesthetic plastic surgery · 2020Article
- HBO Promotes the Differentiation of Neural Stem Cells via Interactions Between the Wnt3/β-Catenin and BMP2 Signaling Pathways.Cell transplantation · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong advanced therapeutic interventions for wounds, hyperbaric oxygen therapy (HBOT) has the unique ability to ameliorate tissue hypoxia, reduce pathologic inflammation, and mitigate ischemia reperfusion injury. Most of the conditions for which it is utilized have few successful alternative treatments, and the morbidity and mortality associated with treatment failure are significant. Data on the efficacy and effectiveness of HBOT were reviewed, comparative effectiveness research of HBOT was explained, and a new paradigm for the appropriate use of HBOT was described.
methodsSystematic reviews and randomized controlled trials that have evaluated HBOT were reviewed.
resultsAlthough numerous small randomized controlled trials provide compelling support for HBOT, the physics of the hyperbaric environment create significant barriers to trial design. The electronic health record infrastructure created to satisfy mandatory quality and registry reporting requirements as part of healthcare reform can be harnessed to facilitate the acquisition of real world data for HBOT comparative effectiveness studies and clinical decision support.
conclusionsPredictive models can identify patients unlikely to heal spontaneously and most likely to benefit from HBOT. Although electronic health records can automate the calculation of predictive models making them available at the point of care, using them in clinical decision making is complicated. It is not clear whether stakeholders will support the allocation of healthcare resources using mathematical models, but the current patient selection process mandates a 30-day delay for all patients who might benefit and allows treatment for at least some patients who cannot benefit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.