Evidence map›Paper›PMID 27556488›Full record

Trial reportNutrients2016

Comparison of Watermelon and Carbohydrate Beverage on Exercise-Induced Alterations in Systemic Inflammation, Immune Dysfunction, and Plasma Antioxidant Capacity.

R Andrew Shanely, David C Nieman, Penelope Perkins-Veazie, Dru A Henson, Mary P Meaney, Amy M Knab, Lynn Cialdell-Kam

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04972552 (Watermelon/UBIQuinone Study), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04972552 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Watermelon/UBIQuinone Study (WUBI-Q Trial)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2021 to 2026Enrolled70ConditionsKidney TransplantationArmscoenzyme Q10, Watermelon diet, Usual Diet, Placebo
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  11. Foods (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

R Andrew ShanelyHuman Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. shanelyra@appstate.edu.
David C NiemanHuman Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. niemandc@appstate.edu.
Penelope Perkins-VeaziePlants for Human Health Institute, North Carolina State University, Department of Horticulture Science, North Carolina Research Campus, 600 Laureate Way, Kannapolis, NC 28081, USA. penelope_perkins@ncsu.edu.
Dru A HensonDepartment of Biology, Appalachian State University, Boone, NC 28608, USA. hensonda@appstate.edu.
Mary P MeaneyHuman Performance Laboratory, Appalachian State University, North Carolina Research Campus, Kannapolis, NC 28081, USA. meaneymp@appstate.edu.
Amy M KnabKinesiology Department, Queens University of Charlotte, Charlotte, NC 28274, USA. knaba@queens.edu.
Lynn Cialdell-KamDepartment of Nutrition, Case Western Reserve University, Cleveland, OH 44106, USA. lak99@case.edu.
Appalachian State University · USCase Western Reserve University · USNorth Carolina State University · USQueens University of Charlotte · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Consuming carbohydrate- and antioxidant-rich fruits during exercise as a means of supporting and enhancing both performance and health is of interest to endurance athletes. Watermelon (WM) contains carbohydrate, lycopene, l-citrulline, and l-arginine. WM may support exercise performance, augment antioxidant capacity, and act as a countermeasure to exercise-induced inflammation and innate immune changes. Trained cyclists (n = 20, 48 ± 2 years) participated in a randomized, placebo controlled, crossover study. Subjects completed two 75 km cycling time trials after either 2 weeks ingestion of 980 mL/day WM puree or no treatment. Subjects drank either WM puree containing 0.2 gm/kg carbohydrate or a 6% carbohydrate beverage every 15 min during the time trials. Blood samples were taken pre-study and pre-, post-, 1 h post-exercise. WM ingestion versus no treatment for 2-weeks increased plasma l-citrulline and l-arginine concentrations (p < 0.0125). Exercise performance did not differ between WM puree or carbohydrate beverage trials (p > 0.05), however, the rating of perceived exertion was greater during the WM trial (p > 0.05). WM puree versus carbohydrate beverage resulted in a similar pattern of increase in blood glucose, and greater increases in post-exercise plasma antioxidant capacity, l-citrulline, l-arginine, and total nitrate (all p < 0.05), but without differences in systemic markers of inflammation or innate immune function. Daily WM puree consumption fully supported the energy demands of exercise, and increased post-exercise blood levels of WM nutritional components (l-citrulline and l-arginine), antioxidant capacity, and total nitrate, but without an influence on post-exercise inflammation and changes in innate immune function.

Indexed as

ExerciseAntioxidantsBeveragesCarbohydratesCitrullusCross-Over StudiesHumansImmune System DiseasesInflammationMaleMiddle AgedTime FactorsAntioxidantsCarbohydratesendurance exercise performanceferric reducing ability of plasma (FRAP)">l-arginine">l-citrullineoxygen radical absorbance capacity (ORAC)total nitrate

Identifiers

PMID27556488
PMCPMC4997430
OpenAlexW2513951720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.