ArticleInternational journal of molecular sciences2016
Synthesis and Evaluation of Novel Oxyalkylated Derivatives of 2',4'-Dihydroxychalcone as Anti-Oomycete Agents against Bronopol Resistant Strains of Saprolegnia sp.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Structure-Activity Relationship of Natural Dihydrochalcones and Chalcones, and Their Respective Oxyalkylated Derivatives as Anti-Plants (Basel, Switzerland) · 2024Article
- Chemical Analysis andMolecules (Basel, Switzerland) · 2021Article
- Sonochemical Synthesis of 2'-Hydroxy-Chalcone Derivatives with Potential Anti-Oomycete Activity.Antibiotics (Basel, Switzerland) · 2020Article
- Synthesis and Anti-Antibiotics (Basel, Switzerland) · 2020Article
- Comparative Therapeutic Effects of Natural Compounds AgainstFrontiers in veterinary science · 2020Article
- Identification of Growth Inhibitors of the Fish PathogenFrontiers in microbiology · 2020Article
- Isolation and identification of compounds from the resinous exudate ofBMC chemistry · 2019Article
- Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens.Molecules (Basel, Switzerland) · 2018Article
- Structure-Activity Relationship of Dialkoxychalcones to Combat Fish PathogenMolecules (Basel, Switzerland) · 2018Article
- Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin.Molecules (Basel, Switzerland) · 2017Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A series of novel oxyalkylchalcones substituted with alkyl groups were designed and synthesized, and the antioomycete activity of the series was evaluated in vitro against Saprolegnia strains. All tested O-alkylchalcones were synthesized by means of nucleophilic substitution from the natural compound 2',4'-dihydroxychalcone (1) and the respective alkyl bromide. The natural chalcone (1) and 10 synthetic oxyalkylchalcones (2-11) were tested against Saprolegnia parasitica and Saprolegnia australis. Among synthetic analogs, 2-hydroxy,4-farnesyloxychalcone (11) showed the most potent activity against Saprolegnia sp., with MIC and MOC values of 125 µg/mL (similar to bronopol at 150 µg/mL) and 175 µg/mL, respectively; however, 2',4'-dihydroxychalcone (1) was the strongest and most active molecule, with MIC and MOC values of 6.25 µg/mL and 12.5 µg/mL.
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