Evidence map›Paper›PMID 27556306›Full record

ArticleBrazilian journal of cardiovascular surgery2016

Associated Clinical and Laboratory Markers of Donor on Allograft Function After Heart Transplant.

Renato Braulio, Marcelo Dias Sanches, Antonio Lúcio Teixeira Junior, Paulo Henrique Nogueira Costa, Maria da Consolação Vieira Moreira, Monaliza Angela Rocha, Silvio Amadeu de Andrade, Cláudio Léo Gelape

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In one paragraph

Article in Brazilian journal of cardiovascular surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Hurdles to Cardioprotection in the Critically Ill.International journal of molecular sciences · 2019
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Renato BraulioFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Marcelo Dias SanchesFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Antonio Lúcio Teixeira JuniorFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Paulo Henrique Nogueira CostaFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Maria da Consolação Vieira MoreiraFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Monaliza Angela RochaFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Silvio Amadeu de AndradeFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Cláudio Léo GelapeFederal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrimary graft dysfunction is a major cause of mortality after heart transplantation.

objectiveTo evaluate correlations between donor-related clinical/biochemical markers and the occurrence of primary graft dysfunction/clinical outcomes of recipients within 30 days of transplant.

methodsThe prospective study involved 43 donor/recipient pairs. Data collected from donors included demographic and echocardiographic information, noradrenaline administration rates and concentrations of soluble tumor necrosis factor receptors (sTNFR1 and sTNFR2), interleukins (IL-6 and IL-10), monocyte chemoattractant protein-1, C-reactive protein and cardiac troponin I. Data collected from recipients included operating, cardiopulmonary bypass, intensive care unit and hospitalization times, inotrope administration and left/right ventricular function through echocardiography.

resultsRecipients who developed moderate/severe left ventricular dysfunction had received organs from significantly older donors (P =0.020). Recipients from donors who required moderate/high doses of noradrenaline (>0.23 µg/kg/min) around harvesting time exhibited lower post-transplant ventricular ejection fractions (P =0.002) and required longer CPB times (P =0.039). Significantly higher concentrations of sTNFR1 (P =0.014) and sTNFR2 (P =0.030) in donors were associated with reduced intensive care unit times (≤5 days) in recipients, while higher donor IL-6 (P =0.029) and IL-10 (P =0.037) levels were correlated with reduced hospitalization times (≤25 days) in recipients. Recipients who required moderate/high levels of noradrenaline for weaning off cardiopulmonary bypass were associated with lower donor concentrations of sTNFR2 (P =0.028) and IL-6 (P =0.001).

conclusionHigh levels of sTNFR1, sTNFR2, IL-6 and IL-10 in donors were associated with enhanced evolution in recipients. Allografts from older donors, or from those treated with noradrenaline doses >0.23 µg/kg/min, were more frequently affected by primary graft dysfunction within 30 days of surgery.

Indexed as

Tissue DonorsAdolescentAdultAge FactorsAllograftsBiomarkersDonor SelectionFemaleHeart TransplantationHumansInterleukinsMaleMiddle AgedNorepinephrinePostoperative PeriodPrimary Graft DysfunctionBiomarkersInterleukinsNorepinephrineReceptors, Tumor Necrosis Factor

Identifiers

PMID27556306
PMCPMC5062732
OpenAlexW2329499430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.