ArticleJournal of applied oral science : revista FOB
Effects of low-level laser therapy on stem cells from human exfoliated deciduous teeth.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Cellular homeostasis and oncology safety of low pulse frequency laser for photobiomodulation in oral and dermal cells.Lasers in medical science · 2026Article
- Effects of 660 and 940nm Low-Level Laser Irradiation on Viability and Proliferation of Stem Cells from Human Exfoliated Deciduous Teeth.Frontiers in dentistry · 2026Article
- The impact of photobiomodulation therapy on the survival and differentiation of periodontal ligament mesenchymal stem cells exposed to zoledronic acid.Scientific reports · 2025Article
- Osteogenic potential of apical papilla stem cells mediated by platelet-rich fibrin and low-level laser.Odontology · 2024Article
- Effect of Low-Level Laser Therapy on Differentiation and Proliferation of Human Dental Pulp Stem Cells: A Systematic Review.Journal of lasers in medical sciences · 2023Review
- Photobiomodulation in 3D tissue engineering.Journal of biomedical optics · 2022Article
- Low-level laser treatment promotes skin wound healing by activating hair follicle stem cells in female mice.Lasers in medical science · 2022Article
- Effects of Two Protocols of Low-Level Laser Therapy on the Proliferation and Differentiation of Human Dental Pulp Stem Cells on Sandblasted Titanium Discs: AnJournal of lasers in medical sciences · 2022Article
- Angiogenic protein synthesis after photobiomodulation therapy on SHED: a preliminary study.Lasers in medical science · 2020Article
- Photobiomodulation-Underlying Mechanism and Clinical Applications.Journal of clinical medicine · 2020Review
- Biological effects of low-level laser irradiation (LLLI) on stem cells from human exfoliated deciduous teeth (SHED).Clinical oral investigations · 2020Article
- Effect of single and multiple doses of low-level laser therapy on viability and proliferation of stem cells from human exfoliated deciduous teeth (SHED).Lasers in medical science · 2019Article
- Laser treatment contributes to maintain membrane integrity in stem cells from human exfoliated deciduous teeth (shed) under nutritional deficit.Lasers in medical science · 2019Article
- Low-level laser irradiation induces in vitro proliferation of stem cells from human exfoliated deciduous teeth.Lasers in medical science · 2018Article
- Effects of PBM in different energy densities and irradiance on maintaining cell viability and proliferation of pulp fibroblasts from human primary teeth.Lasers in medical science · 2017Article
- Cytotoxicity of gypsum-based biomaterial for direct pulp capping using stem cells from human exfoliated deciduous teeth.Journal of conservative dentistry : JCDArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to evaluate the influence of different laser therapy energy densities on SHED viability and proliferation. MATERIAL AND
methodsSHED were irradiated according to the groups: I (1.2 J/cm2 - 0.5 mW - 10 s), II (2.5 J/cm2 - 10 mW - 10 s), III (3.7 J/cm2 - 15 mW - 10 s), IV (5.0 J/cm2 - 20 mW - 10 s), V (6.2 J/cm2 - 25 mW - 10 s), and VI (not irradiated - control group). Cell viability was assessed 6 and 24 h after irradiation measuring the mitochondrial activity and using the Crystal Violet assay. Cell proliferation was assessed after 24, 48, and 72 h of irradiation by SRB assay.
resultsMTT assay demonstrated differences from 6 to 24 hours after irradiation. After 24 h, groups I and IV showed higher absorbance values than those of control group. Crystal Violet assay showed statistically differences in the absorbance rate from 6 to 24 h after irradiation for groups III and VI. At 24 h after irradiation, Group III absorbance rate was greater than that of groups I, II, and IV. Group VI absorbance rate was greater than that of groups I and IV. SRB assay showed that the group I had higher rates than those of groups II, III, V, and VI, at 24 h after irradiation. After 48 h, group I exhibited the greatest cell proliferation rate followed by groups III, V, and VI. After 72 h, group III exhibited the lowest cell proliferation rate than those of groups II, IV, and V.
conclusionsThe Low-Level Laser Therapy energy densities used in this study did not cause loss of cell viability and stimulated SHED proliferation within the parameters described in this study.
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