SynthesisClinical cardiology2016
Meta-analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation.
Synthesis in Clinical cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Pooled it
- Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies.Nutrition journal · 2019Pooled it
- Trial
- Effects of high-dose vitamin D supplementation on the occurrence of post-operative atrial fibrillation after coronary artery bypass grafting: randomized controlled trial.General thoracic and cardiovascular surgery · 2020Trial
- Effect of Plasma Level of Vitamin D on Postoperative Atrial Fibrillation in Patients Undergoing Isolated Coronary Artery Bypass Grafting.Brazilian journal of cardiovascular surgeryTrial
- Vitamin-D and associated biomarker profiles in patients with chronic heart failure.Pakistan journal of medical sciences · 2026Article
- Loneliness, insomnia symptoms, social jetlag, and vitamin D deficiency in relation to mental health problems in Japanese female university students: a cross-sectional study.Journal of physiological anthropology · 2025Article
- Review
- The decline of vitamin D in adolescent athletes: insights from a one-year follow-up and its association with electrocardiographic changes.Frontiers in cardiovascular medicine · 2025Article
- General and sex-specific effects of vitamin D against atrial fibrillation and young-onset ischemic stroke: a Mendelian randomization series.Journal of clinical biochemistry and nutrition · 2024Article
- Vitamin D and Cardiovascular Diseases: An Update.Cureus · 2023Review
- The Possible Influence of Vitamin D Levels on the Development of Atrial Fibrillation-An Update.Nutrients · 2023Review
- Comparing the Evidence from Observational Studies and Randomized Controlled Trials for Nonskeletal Health Effects of Vitamin D.Nutrients · 2022Review
- Vitamin D and cardiovascular disease risk. A literature overview.Molecular biology reports · 2022Review
- Relationship between vitamin D deficiency and success of cardioversion in patients with atrial fibrillation.Herzschrittmachertherapie & Elektrophysiologie · 2022Article
- The Pathogenesis of Cardiac Arrhythmias in Vitamin D Deficiency.Biomedicines · 2022Review
- Circulating Vitamin D Levels and the Risk of Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.Frontiers in nutrition · 2022Article
- Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics.Frontiers in nutrition · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are accumulating studies investigating the association between vitamin D status and the risk of atrial fibrillation (AF). However, the results in these studies were inconsistent in regard to the role of vitamin D deficiency in predicting the development of AF. HYPOTHESIS: Vitamin D deficiency is associated increased risk of AF.
methodsUsing PubMed and Embase databases, we searched for records published before March 2016. Additionally, a manual search was conducted using all review articles on this topic. Of the 587 initially identified records, 8 studies with a total of 27 307 patients were finally analyzed.
resultsIn the categorical variable analysis, vitamin D deficiency was associated with the occurrence of AF (odds ratio: 1.31, 95% confidence interval: 1.06-1.62, P = 0.01). In the continuous variable analysis, higher vitamin D levels appear to protect against the development of AF (odds ratio: 0.92, 95% confidence interval: 0.87-0.97, P = 0.002). However, the association is weak on the pooled analysis of prospective cohort studies focused on new-onset AF (P = 0.07 and 0.04), whereas the pooled analysis of case-control studies mainly assessing for chronic AF strongly support such an association (both P < 0.0001).
conclusionsVitamin D deficiency modestly increases the risk of AF. Further studies are needed to determine the if there is a direct causal relationship between vitamin D levels and AF and whether vitamin D supplements will prevent new-onset AF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.