ArticleWorld journal of diabetes2016
Increased fecal viral content associated with obesity in mice.
Article in World journal of diabetes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Modulation of Microbiome-Mitochondria Axis as a Novel Approach for Treatment of Obesity: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation.Aging and disease · 2025Review
- Gut microbiomes and treatment-resistant ulcerative colitis: a case-control study using qPCR.BMC microbiology · 2025Article
- The human gut phageome: composition, development, and alterations in disease.Frontiers in microbiology · 2023Review
- Characterization of the human gut virome in metabolic and autoimmune diseases.Inflammation and regeneration · 2022Review
- The Human Virome: Viral Metagenomics, Relations with Human Diseases, and Therapeutic Applications.Viruses · 2022Review
- Viral metagenomics combined with metabolomics reveals the role of gut viruses in mouse model of depression.Frontiers in microbiology · 2022Article
- The critical role of gut microbiota in obesity.Frontiers in endocrinology · 2022Review
- Observational
- Article
- Perinatal Nutritional and Metabolic Pathways: Early Origins of Chronic Lung Diseases.Frontiers in medicine · 2021Review
- Viral Infections and Interferons in the Development of Obesity.Biomolecules · 2019Review
- A theoretical model of temperate phages as mediators of gut microbiome dysbiosis.F1000Research · 2019Review
- Bi-directional drug-microbiome interactions of anti-diabetics.EBioMedicine · 2019Review
- A Wake-Up Call: We Need Phage Therapy Now.Viruses · 2018Review
- Stable core virome despite variable microbiome after fecal transfer.Gut microbes · 2017Review
- Fecal microbiota transplantation-early steps on a long journey ahead.Gut microbes · 2017Article
- Dietary fiber for the prevention of childhood obesity: a focus on the involvement of the gut microbiota.Gut microbesReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the presence of total gut viral content in obese mice, and establish correlation with obesity associated metabolic measures and gut microbiome.
methodsFresh fecal samples were collected from normal and obese (Leptin deficient: Lep(ob/ob)) mice. Total viral DNA and RNA was isolated and quantified for establishing the correlation with metabolic measures and composition of gut bacterial communities.
resultsIn this report, we found that obese mice feces have higher viral contents in terms of total viral DNA and RNA (P < 0.001). Interestingly, these increased viral DNA and RNA content were tightly correlated with metabolic measures, i.e., body weight, fat mass and fasting blood glucose. Total viral content were positively correlated with firmicutes (R(2) > 0.6), whilst negatively correlated with bacteroidetes and bifidobacteria.
conclusionThis study suggests the strong correlation of increased viral population into the gut of obese mice and opens new avenues to explore the role of gut virome in pathophysiology of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.