ArticleFrontiers in microbiology2016
Murine Model Imitating Chronic Wound Infections for Evaluation of Antimicrobial Photodynamic Therapy Efficacy.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Light-based therapy of infected wounds: a review of dose considerations for photodynamic microbial inactivation and photobiomodulation.Journal of biomedical optics · 2025Review
- A murine pressure ulcer model for evaluating persistence and treatment ofFrontiers in medicine · 2025Article
- Development of photoactive biomaterial using modified fullerene nanoparticles.Frontiers in chemistry · 2024Article
- Antibacterial and anti-corona virus (229E) activity of Nigella sativa oil combined with photodynamic therapy based on methylene blue in wound infection: in vitro and in vivo study.BMC microbiology · 2023Article
- Antimicrobial Resistance: Is There a 'Light' at the End of the Tunnel?Antibiotics (Basel, Switzerland) · 2023Review
- Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing.Nature biotechnology · 2023Article
- Porphyrin nanoemulsion for antimicrobial photodynamic therapy: effective delivery to inactivate biofilm-related infections.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo.Pharmaceutics · 2021Article
- The Role of Porphyrinoid Photosensitizers for Skin Wound Healing.International journal of molecular sciences · 2021Review
- Photodynamic Antimicrobial Chemotherapy: Advancements in Porphyrin-Based Photosensitize Development.Frontiers in chemistry · 2021Review
- Comparison of Antibacterial Activity and Wound Healing in a Superficial Abrasion Mouse Model ofFrontiers in medicine · 2021Article
- Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review.Turkish archives of otorhinolaryngology · 2020Review
- Monosubstituted tricationic Zn(II) phthalocyanine enhances antimicrobial photodynamic inactivation (aPDI) of methicillin-resistantEmerging microbes & infections · 2020Article
- Research Techniques Made Simple: Mouse Bacterial Skin Infection Models for Immunity Research.The Journal of investigative dermatology · 2020Article
- Antifungal Photodynamic Activity of Hexyl-Aminolevulinate Ethosomes AgainstFrontiers in microbiology · 2020Article
- Article
- Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus.Journal of microbiology (Seoul, Korea) · 2018Article
- Photo-Crosslinked Polymeric Matrix with Antimicrobial Functions for Excisional Wound Healing in Mice.Nanomaterials (Basel, Switzerland) · 2018Article
- Rose Bengal-Mediated Photoinactivation of Multidrug ResistantFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally acknowledged that the age of antibiotics could come to an end, due to their widespread, and inappropriate use. Particularly for chronic wounds alternatives are being thought. Antimicrobial Photodynamic Therapy (APDT) is a potential candidate, and while approved for some indications, such as periodontitis, chronic sinusitis and other niche indications, its use in chronic wounds is not established. To further facilitate the development of APDT in chronic wounds we present an easy to use animal model exhibiting the key hallmarks of chronic wounds, based on full-thickness skin wounds paired with an optically transparent cover. The moisture-retaining wound exhibited rapid expansion of pathogen colonies up to 8 days while not jeopardizing the host survival. Use of two bioluminescent pathogens; methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa permits real time monitoring of the pathogens. The murine model was employed to evaluate the performance of four different photosensitizers as mediators in Photodynamic Therapy. While all four photosensitizers, Rose Bengal, porphyrin TMPyP, New Methylene Blue, and TLD1411 demonstrated good to excellent antimicrobial efficacy in planktonic solutions at 1 to 50 μM concentrations, whereas in in vivo the growth delay was limited with 24-48 h delay in pathogen expansion for MRSA, and we noticed longer growth suppression of P. aeruginosa with TLD1411 mediated Photodynamic Therapy. The murine model will enable developing new strategies for enhancement of APDT for chronic wound infections.
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