Evidence map›Paper›PMID 27555764›Full record

ArticleInternational journal of nanomedicine2016

Gallic acid conjugated with gold nanoparticles: antibacterial activity and mechanism of action on foodborne pathogens.

Narintorn Rattanata, Sompong Klaynongsruang, Chanvit Leelayuwat, Temduang Limpaiboon, Aroonlug Lulitanond, Patcharee Boonsiri, Sirinart Chio-Srichan, Siriwat Soontaranon, Supagorn Rugmai, Jureerut Daduang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  13. Toxicity of gold nanoparticles (AuNPs): A review.Biochemistry and biophysics reports · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Narintorn RattanataDepartment of Biochemistry, Faculty of Science.
Sompong KlaynongsruangDepartment of Biochemistry, Faculty of Science.
Chanvit LeelayuwatCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences.
Temduang LimpaiboonCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences.
Aroonlug LulitanondCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences.
Patcharee BoonsiriDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen.
Sirinart Chio-SrichanSynchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand.
Siriwat SoontaranonSynchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand.
Supagorn RugmaiSynchrotron Light Research Institute (Public Organization), Nakhon Ratchasima, Thailand.
Jureerut DaduangCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences.
Medical Diagnostic Laboratories (United States) · USSynchrotron Light Research Institute · THCentre for Research and Development · ZWKhon Kaen University · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foodborne pathogens, including Plesiomonas shigelloides and Shigella flexneri B, are the major cause of diarrheal endemics worldwide. Antibiotic drug resistance is increasing. Therefore, bioactive compounds with antibacterial activity, such as gallic acid (GA), are needed. Gold nanoparticles (AuNPs) are used as drug delivery agents. This study aimed to conjugate and characterize AuNP-GA and to evaluate the antibacterial activity. AuNP was conjugated with GA, and the core-shell structures were characterized by small-angle X-ray scattering and transmission electron microscopy. Antibacterial activity of AuNP-GA against P. shigelloides and S. flexneri B was evaluated by well diffusion method. AuNP-GA bactericidal mechanism was elucidated by Fourier transform infrared microspectroscopic analysis. The results of small-angle X-ray scattering showed that AuNP-GA conjugation was successful. Antibacterial activity of GA against both bacteria was improved by conjugation with AuNP because the minimum inhibitory concentration value of AuNP-GA was significantly decreased (P<0.0001) compared to that of GA. Fourier transform infrared analysis revealed that AuNP-GA resulted in alterations of lipids, proteins, and nucleic acids at the bacterial cell membrane. Our findings show that AuNP-GA has potential for further application in biomedical sciences.

Indexed as

Anti-Bacterial AgentsBacteriaFoodborne DiseasesGallic AcidGoldMetal NanoparticlesMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionScattering, Small AngleSpectroscopy, Fourier Transform InfraredX-Ray DiffractionAnti-Bacterial AgentsGallic AcidGoldantibacterial activityfoodborne bacteriagallic acidgold nanoparticlessmall-angle X-ray scattering (SAXS)

Identifiers

PMID27555764
PMCPMC4968851
OpenAlexW2476402939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.