ArticleInternational journal of chronic obstructive pulmonary disease2016
Alteration of spontaneous brain activity in COPD patients.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Abnormal Alternations of Brain Imaging in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review.Journal of Alzheimer's disease reports · 2023Pooled it
- Multidimensional cortical morphological alterations in COPD using explainable machine learning.iScience · 2026Article
- Bidirectional cortical gyrification alterations in chronic obstructive pulmonary disease: links to cognitive impairment and global initiative for chronic obstructive lung disease staging.BMC medical imaging · 2026Article
- Brain structural changes in COPD patients with cognitive impairment.Journal of neurology · 2026Review
- Observational
- Aberrant brain functional network in COPD patients with cognitive impairment: clinical manifestations, mechanisms and therapeutic strategies.Journal of neuroinflammation · 2025Review
- Relationship between Pulmonary Gas Exchange Function and Brain Uptake Dynamics Investigated with HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters.International journal of chronic obstructive pulmonary disease · 2025Article
- Functional connectivity alterations in the thalamus among patients with bronchial asthma.Frontiers in neurology · 2024Article
- The adjusted impact of different severities of acute exacerbations and medications on the risk of developing dementia in COPD patients.BMC pulmonary medicine · 2023Article
- Abnormal static and dynamic functional network connectivity in stable chronic obstructive pulmonary disease.Frontiers in aging neuroscience · 2022Article
- Article
- Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study.Brain imaging and behavior · 2020Article
- Abnormal intrinsic brain activities in stable patients with COPD: a resting-state functional MRI study.Neuropsychiatric disease and treatment · 2018Article
- Alterations of the default mode network and cognitive impairments in patients with chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2018Article
- Mechanism of Cerebralcare Granule® for Improving Cognitive Function in Resting-State Brain Functional Networks of Sub-healthy Subjects.Frontiers in neuroscience · 2017Article
- Disrupted resting-state spontaneous neural activity in stable COPD.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveAirflow limitation in chronic obstructive pulmonary disease (COPD) results in a decrease in oxygen transport to the brain. The aim of the present study was to explore the alteration of spontaneous brain activity induced by hypoxia in patients with COPD. PATIENTS AND
methodsTwenty-five stable patients with COPD and 25 matching healthy volunteers were investigated. Amplitude of low-frequency fluctuation (ALFF) of blood oxygenation level-dependent signal at resting state in the brain was analyzed using functional magnetic resonance imaging.
resultsWhole-brain analysis using functional magnetic resonance imaging revealed significant decreases in ALFF in the bilateral posterior cingulate gyri and right lingual gyrus and an increase in ALFF in the left postcentral gyrus of patients with COPD. After controlling for SaO2, patients with COPD only showed an increase in ALFF in the left postcentral gyrus. Region of interest analysis showed a decrease in ALFF in the left precentral gyrus and an increase in ALFF in the left caudate nucleus of patients with COPD. In all subjects, ALFF in the bilateral posterior cingulate gyri and right lingual gyrus showed positive correlations with visual reproduction.
conclusionWe demonstrated abnormal spontaneous brain activity of patients with COPD, which may have a pathophysiologic meaning.
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