ArticleInternational journal of chronic obstructive pulmonary disease2016
Respiratory muscle strength effect on linear and nonlinear heart rate variability parameters in COPD patients.
Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of heart rate variability in COPD.Frontiers in cardiovascular medicine · 2023Pooled it
- Influence of expiratory positive airway pressure on cardiac autonomic modulation at rest and in submaximal exercise in COPD patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Trial
- Is cardiac autonomic modulation during upper limb isometric contraction and Valsalva maneuver impaired in COPD patients?International journal of chronic obstructive pulmonary disease · 2017Trial
- Heart rate variability metrics and myocardial recovery in heart failure with reduced ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Association of heart rate variability with cardiorespiratory fitness and muscle strength in patients after hospitalization for COVID-19: An analytical cross-sectional study.Clinics (Sao Paulo, Brazil) · 2024Article
- Use of a Wearable Biosensor to Study Heart Rate Variability in Chronic Obstructive Pulmonary Disease and Its Relationship to Disease Severity.Sensors (Basel, Switzerland) · 2022Article
- The Indices of Instantaneous Pulse Rate Variability Are Indicators for Daily Life Quality Assessment in Patients with COPD.Journal of healthcare engineering · 2022Article
- Sympathetic and Vagal Nerve Activity in COPD: Pathophysiology, Presumed Determinants and Underappreciated Therapeutic Potential.Frontiers in physiology · 2022Review
- Application of the Variance Delay Fuzzy Approximate Entropy for Autonomic Nervous System Fluctuation Analysis in Obstructive Sleep Apnea Patients.Entropy (Basel, Switzerland) · 2020Article
- COPD Patients Have a Restricted Breathing Pattern That Persists with Increased Metabolic Demands.COPD · 2020Article
- Complexity analysis of heart rate variability in chronic obstructive pulmonary disease: relationship with severity and symptoms.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020Article
- Subjects With COPD Walk With Less Consistent Organization of Movement Patterns of the Lower Extremity.Respiratory care · 2020Article
- A Transfer Entropy Approach for the Assessment of the Impact of Inspiratory Muscle Training on the Cardiorespiratory Coupling of Amateur Cyclists.Frontiers in physiology · 2020Article
- Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling.Frontiers in physiology · 2020Article
- Impact of chronic obstructive pulmonary disease on linear and nonlinear dynamics of heart rate variability in patients with heart failure.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Influence of Chronic Obstructive Pulmonary Disease and Moderate-To-Severe Sleep Apnoea in Overnight Cardiac Autonomic Modulation: Time, Frequency and Non-Linear Analyses.Entropy (Basel, Switzerland) · 2019Article
- Entropy Change of Biological Dynamics in Asthmatic Patients and Its Diagnostic Value in Individualized Treatment: A Systematic Review.Entropy (Basel, Switzerland) · 2018Review
- Entropy change of biological dynamics in COPD.International journal of chronic obstructive pulmonary disease · 2017Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic obstructive pulmonary disease (COPD) is recognized as a multisystemic inflammatory disease associated with extrapulmonary comorbidities, including respiratory muscle weakness and cardiovascular and cardiac autonomic regulation disorders. We investigated whether alterations in respiratory muscle strength (RMS) would affect cardiac autonomic modulation in COPD patients.
methodsThis study was a cross-sectional study done in ten COPD patients affected by moderate to very severe disease. The heart rate variability (HRV) signal was recorded using a Polar cardiofrequencimeter at rest in the sitting position (10 minutes) and during a respiratory sinus arrhythmia maneuver (RSA-M; 4 minutes). Linear analysis in the time and frequency domains and nonlinear analysis were performed on the recorded signals. RMS was assessed using a digital manometer, which provided the maximum inspiratory pressure (PImax) and the maximum expiratory pressure (PEmax).
resultsDuring the RSA-M, patients presented an HRV power increase in the low-frequency band (LFnu) (46.9±23.7 vs 75.8±27.2; P=0.01) and a decrease in the high-frequency band (HFnu) (52.8±23.5 vs 24.0±27.0; P=0.01) when compared to the resting condition. Significant associations were found between RMS and HRV spectral indices: PImax and LFnu (r=-0.74; P=0.01); PImax and HFnu (r=0.74; P=0.01); PEmax and LFnu (r=-0.66; P=0.01); PEmax and HFnu (r=0.66; P=0.03); between PEmax and sample entropy (r=0.83; P<0.01) and between PEmax and approximate entropy (r=0.74; P=0.01). Using a linear regression model, we found that PImax explained 44% of LFnu behavior during the RSA-M.
conclusionCOPD patients with impaired RMS presented altered cardiac autonomic control, characterized by marked sympathetic modulation and a reduced parasympathetic response; reduced HRV complexity was observed during the RSA-M.
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