ArticleClinical interventions in aging2016
Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment.
Article in Clinical interventions in aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Silver nanoparticles combine with Nigella sativa oil to potentiate apoptosis in cervical cancer.Scientific reports · 2026Article
- Genetic and clinical aspects of TMC1-related hearing loss in Iranian families: identification of two novel variants.Molecular biology reports · 2025Article
- Analysis and identification of mitochondria-related genes associated with age-related hearing loss.BMC genomics · 2025Article
- Cognitive Impairment in Nonagenarians: Potential Metabolic Mechanisms Revealed by the Synergy of In Silico Gene Expression Modeling and Pathway Enrichment Analysis.International journal of molecular sciences · 2024Article
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- Extracellular Biomarkers of Inner Ear Disease and Their Potential for Point-of-Care Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us.Journal of cellular and molecular medicine · 2021Review
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- Gene expression vs. sequence divergence: comparative transcriptome sequencing among naturalFrontiers in zoology · 2019Article
- MicroRNAs and Presbycusis.Aging and disease · 2018Review
- Acute Noise Exposure Is Associated With Intrinsic Apoptosis in Murine Central Auditory Pathway.Frontiers in neuroscience · 2018Article
- Downregulation of microRNA-125a is involved in intervertebral disc degeneration by targeting pro-apoptotic Bcl-2 antagonist killer 1.Iranian journal of basic medical sciences · 2017Article
- Analysis of DNA methylation in chondrocytes in rats with knee osteoarthritis.BMC musculoskeletal disorders · 2017Article
- Association of genetic variations in the mitochondrial DNA control region with presbycusis.Clinical interventions in aging · 2017Article
- The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis.Therapeutics and clinical risk management · 2016Article
- The Effect of Intra-articular versus Intravenous Injection of Mesenchymal Stem Cells on Experimentally-Induced Knee Joint Osteoarthritis.Journal of microscopy and ultrastructureArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Age-related hearing impairment (ARHI) is a progressive and a common sensory disorder in the elderly and will become an increasingly important clinical problem given the growing elderly population. Apoptosis of cochlear cells is an important factor in animal models of ARHI. As these cells cannot regenerate, their loss leads to irreversible hearing impairment. Identification of molecular mechanisms can facilitate disease prevention and effective treatment. In this study, we compared the expression of the genes BAK1 and BCL2 as two arms of the intrinsic apoptosis pathway between patients with ARHI and healthy subjects. ARHI and healthy subjects were selected after an ear nose throat examination, otoscopic investigation, and pure tone audiometry. RNA was extracted from peripheral blood samples, and relative gene expression levels were measured using quantitative real-time polymerase chain reaction. BAK1 and the BAK1/BCL2 ratio were statistically significantly upregulated in the ARHI subjects. The BAK1/BCL2 ratio was positively correlated with the results of the audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of ARHI in humans, similar to finding in animal models. Moreover, the gene expression changes in peripheral blood samples could be used as a rapid and simple biomarker for early detection of ARHI.
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