ReviewClinical science (London, England : 1979)2016
Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine.
Review in Clinical science (London, England : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Cellular senescence and chronological age in various human tissues: A systematic review and meta-analysis.Aging cell · 2020Pooled it
- Pooled it
- Trial
- Trial
- Differences across males and females in cognitive aging and mortality risk: a trajectory-based approach.GeroScience · 2026Article
- Associations of extreme temperature and relative humidity with hematological disease mortality in Chuzhou, China.Scientific reports · 2026Article
- Global, regional, and national trends in blindness and vision loss, 1990-2021: a secondary ecological trend analysis based on modelled population estimates.Journal of global health · 2026Article
- Tracking DNA methylation-based biological age over 8 years and its association with mortality in community-dwelling older adults.Clinical epigenetics · 2026Article
- Lip Pressure, Bite Force and Denture Use as Predictors of Oral Frailty in Physically Active Older Adults: A Cross-Sectional Study.Dentistry journal · 2026Article
- Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.Molecular neurodegeneration · 2026Article
- Trends in Alzheimer's disease and heart failure-related mortality among older American adults: Insights from the CDC WONDER database.American heart journal plus : cardiology research and practice · 2025Article
- Epigenetic Clock Analysis of Sex Chromosome Aneuploidies.Aging cell · 2025Article
- Inflammaging and the sex-frailty paradox.Aging clinical and experimental research · 2025Article
- Rising Deaths due to Malnutrition and Growing Disparities in the U.S.: A 24-Year Trend Analysis From 1999 and 2023.Food science & nutrition · 2025Article
- The Influence of Sex and Sex-Steroid Hormones on Cerebellar Structure and Functional Connectivity Across Adulthood.Human brain mapping · 2025Article
- Evaluation of serum samples in long cryopreservation for SomaScan proteomics and sex differences in elderly Japanese adults.Scientific reports · 2025Observational
- The elderly as a population at risk of chronic obstructive pulmonary disease mortality due to ambient ozone exposure: results from the Global Burden of Disease Study 2021.Environmental health : a global access science source · 2025Article
- Replication stress responses in human lymphocytes change sex-specifically during aging.Nucleic acids research · 2025Article
- Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Data showing a remarkable gender difference in life expectancy and mortality, including survival to extreme age, are reviewed starting from clinical and demographic data and stressing the importance of a comprehensive historical perspective and a gene-environment/lifestyle interaction. Gender difference regarding prevalence and incidence of the most important age-related diseases, such as cardiovascular and neurodegenerative diseases, cancer, Type 2 diabetes, disability, autoimmunity and infections, are reviewed and updated with particular attention to the role of the immune system and immunosenescence. On the whole, gender differences appear to be pervasive and still poorly considered and investigated despite their biomedical relevance. The basic biological mechanisms responsible for gender differences in aging and longevity are quite complex and still poorly understood. The present review focuses on centenarians and their offspring as a model of healthy aging and summarizes available knowledge on three basic biological phenomena, i.e. age-related X chromosome inactivation skewing, gut microbiome changes and maternally inherited mitochondrial DNA genetic variants. In conclusion, an appropriate gender-specific medicine approach is urgently needed and should be systematically pursued in studies on healthy aging, longevity and age-related diseases, in a globalized world characterized by great gender differences which have a high impact on health and diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.