Evidence map›Paper›PMID 27555320›Full record

ArticleThe Journal of biological chemistry2016

Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.

Jeong-Yun Choi, Amritaj Patra, Mina Yeom, Young-Sam Lee, Qianqian Zhang, Martin Egli, F Peter Guengerich

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. 8-Oxoadenine: A «New» Player of the Oxidative Stress in Mammals?International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Jeong-Yun ChoiFrom the Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Gyeonggi-do 16419, Republic of Korea.
Amritaj Patrathe Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and.
Mina YeomFrom the Division of Pharmacology, Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Gyeonggi-do 16419, Republic of Korea.
Young-Sam Leethe Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology, Daegu 42988, Republic of Korea.
Qianqian Zhangthe Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and.
Martin Eglithe Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and.
F Peter Guengerichthe Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and f.guengerich@vanderbilt.edu.
Vanderbilt University · USDaegu Gyeongbuk Institute of Science and Technology · KRSamsung (South Korea) · KRSungkyunkwan University · KR

Funding

Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
BIOACTIVATION OF HALOGENATED HYDROCARBONSR01ES010546 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2001 to 2020
$8.1M
POLYMERASE INTERACTIONS WITH CARCINOGEN MODIFIED DNAR01ES010375 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2000 to 2014
$5.9M
NCI NIH HHS P01 CA160032NIEHS NIH HHS R01 ES010375NIEHS NIH HHS R01 ES010546
6 · The paper itself

Abstract

DNA polymerase (pol) ι is a Y-family polymerase involved in translesion synthesis, exhibiting higher catalytic activity with Mn

Indexed as

Mutation, MissenseAmino Acid SubstitutionCrystallography, X-RayDeoxycytosine NucleotidesDNA-Directed DNA PolymeraseDNA Polymerase iotaHumansHydrogen BondingKineticsMagnesiumManganeseProtein Domains2'-deoxycytidine 5'-triphosphateDeoxycytosine NucleotidesDNA-Directed DNA PolymeraseDNA Polymerase iotaMagnesiumManganesePOLI protein, humancrystal structureDNA enzymeDNA polymeraseenzyme kineticsgenetic variationkineticsmetal ion-protein interactionpre-steady-state kineticstranslesion DNA synthesisX-ray crystallography

Identifiers

PMID27555320
PMCPMC5076516
OpenAlexW2513255906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.