ArticleNeurobiology of learning and memory2016
Long-term habituation of the C-start escape response in zebrafish larvae.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning.Environmental health perspectives · 2026Article
- Review
- Differences in Colour Pattern, Behaviour and Gene Expression in the Brain Suggest Divergent Camouflage Strategies in Sympatric Reef Fish Species.Molecular ecology · 2025Article
- Surrogate GPR139 Agonists Reverse Short-Term Startle Habituation Impairment in Larval Zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Article
- Habituation learning: insights from zebrafish larvae.Frontiers in molecular neuroscience · 2025Review
- HypomyelinatedInternational journal of molecular sciences · 2024Article
- Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish.eLife · 2023Article
- Learning and memory formation in zebrafish: Protein dynamics and molecular tools.Frontiers in cell and developmental biology · 2023Review
- A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish-Focussing on Neurobehavioural and Psychological Responses.Brain sciences · 2022Review
- Brain-wide visual habituation networks in wild type and fmr1 zebrafish.Nature communications · 2022Article
- Light-stimulus intensity modulates startle reflex habituation in larval zebrafish.Scientific reports · 2021Article
- Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- A model-based quantification of startle reflex habituation in larval zebrafish.Scientific reports · 2021Article
- Stimulus Contrast Information Modulates Sensorimotor Decision Making in Goldfish.Frontiers in neural circuits · 2020Article
- Behavioral studies of stimulus learning in zebrafish larvae.Behavioural processes · 2019Review
- Are the persistent effects of "gate control" stimulation on nociception a form of generalization of habituation that is endocannabinoid-dependent?Neurobiology of learning and memory · 2018Article
- Effects of Social Experience on the Habituation Rate of Zebrafish Startle Escape Response: Empirical and Computational Analyses.Frontiers in neural circuits · 2018Article
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7 authors at 2 institutions in 1 country.
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Abstract
The cellular and molecular basis of long-term memory in vertebrates remains poorly understood. Knowledge regarding long-term memory has been impeded by the enormous complexity of the vertebrate brain, particularly the mammalian brain, as well as by the relative complexity of the behavioral alterations examined in most studies of long-term memory in vertebrates. Here, we demonstrate a long-term form of nonassociative learning-specifically, long-term habituation (LTH)-of a simple reflexive escape response, the C-start, in zebrafish larvae. The C-start is triggered by the activation of one of a pair of giant neurons in the zebrafish's hindbrain, the Mauthner cells. We show that LTH of the C-start requires the activity of NMDA receptors and involves macromolecular synthesis. We further show that the long-term habituated reflex can by rapidly dishabituated by a brief tactile stimulus. Our results set the stage for rigorous, mechanistic investigations of the long-term memory for habituation of a reflexive behavioral response, one that is mediated by a relatively simple, neurobiologically tractable, neural circuit. Moreover, the demonstration of NMDAR and transcriptionally dependent LTH in a translucent vertebrate organism should facilitate the use of optical recording, and optogenetic manipulation, of neuronal activity to elucidate the cellular basis of a long-term vertebrate memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.