Evidence map›Paper›PMID 27554995›Full record

ArticleOsteoarthritis and cartilage2017

The use of a cartilage decellularized matrix scaffold for the repair of osteochondral defects: the importance of long-term studies in a large animal model.

R A Vindas Bolaños, S M Cokelaere, J M Estrada McDermott, K E M Benders, U Gbureck, S G M Plomp, H Weinans, J Groll, P R van Weeren, J Malda

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In one paragraph

Article in Osteoarthritis and cartilage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Animal Models of Osteochondral Defect for Testing Biomaterials.Biochemistry research international · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

R A Vindas BolañosCátedra de Cirugía de Especies Mayores, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
S M CokelaereDepartment of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J M Estrada McDermottCátedra de Cirugía de Especies Mayores, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
K E M BendersDepartment of Orthopaedics, Division of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
U GbureckDepartment of Functional Materials in Medicine and Dentistry, University of Würzburg, Würzburg, Germany.
S G M PlompDepartment of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
H WeinansDepartment of Orthopaedics, Division of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
J GrollDepartment of Functional Materials in Medicine and Dentistry, University of Würzburg, Würzburg, Germany.
P R van WeerenDepartment of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
J MaldaDepartment of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands; Department of Orthopaedics, Division of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: j.malda@umcutrecht.nl.

Funding

European Research Council 647426
6 · The paper itself

Abstract

objectiveTo investigate the effect of decellularized cartilage-derived matrix (CDM) scaffolds, by itself and as a composite scaffold with a calcium phosphate (CaP) base, for the repair of osteochondral defects. It was hypothesized that the chondral defects would heal with fibrocartilaginous tissue and that the composite scaffold would result in better bone formation.

methodsAfter an 8-week pilot experiment in a single horse, scaffolds were implanted in eight healthy horses in osteochondral defects on the medial trochlear ridge of the femur. In one joint a composite CDM-CaP scaffold was implanted (+P), in the contralateral joint a CDM only (-P) scaffold. After euthanasia at 6 months, tissues were analysed by histology, immunohistochemistry, micro-CT, biochemistry and biomechanical evaluation.

resultsThe 8-week pilot showed encouraging formation of bone and cartilage, but incomplete defect filling. At 6 months, micro-CT and histology showed much more limited filling of the defect, but the CaP component of the +P scaffolds was well integrated with the surrounding bone. The repair tissue was fibrotic with high collagen type I and low type II content and with no differences between the groups. There were also no biochemical differences between the groups and repair tissue was much less stiff than normal tissue (P < 0.0001).

conclusionsThe implants failed to produce reasonable repair tissue in this osteochondral defect model, although the CaP base in the -P group integrated well with the recipient bone. The study stresses the importance of long-term in vivo studies to assess the efficacy of cartilage repair techniques.

Indexed as

Tissue ScaffoldsAnimalsCartilageCartilage, ArticularDisease Models, AnimalHorsesX-Ray MicrotomographyAnimal modelsCartilageEquine modelLong-term studyOsteochondral defectScaffolds

Identifiers

PMID27554995
PMCPMC7116104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.