Evidence map›Paper›PMID 27554943›Full record

Trial reportScientific reports2016

Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials.

Audrey Bergouignan, Celine Latouche, Sarah Heywood, Megan S Grace, Medini Reddy-Luthmoodoo, Alaina K Natoli, Neville Owen, David W Dunstan, Bronwyn A Kingwell

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 6 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 6 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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  17. Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026
    Review
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  20. Association of wearableZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Audrey BergouignanPhysical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Celine LatoucheMetabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Sarah HeywoodMetabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Megan S GracePhysical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Medini Reddy-LuthmoodooMetabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Alaina K NatoliMetabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Neville OwenPhysical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
David W DunstanPhysical Activity Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Bronwyn A KingwellMetabolic and Vascular Physiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Baker Heart and Diabetes Institute · AUAustralian Catholic University · AUMonash University · AUUniversity of Melbourne · AU

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Paul S. Maclean · 1995 to 2026
$32.6M
Functional aspects of SREBP1c in intact skeletal muscleK01DK067403 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MACLEAN, PAUL S · 2005 to 2007
$397k
6 · The paper itself

Abstract

Epidemiological studies have observed associations between frequent interruptions of sitting time with physical activity bouts and beneficial metabolic outcomes, even in individuals who regularly exercise. Frequent interruptions to prolonged sitting reduce postprandial plasma glucose. Here we studied potential skeletal muscle mechanisms accounting for this improved control of glycemia in overweight adults under conditions of one day uninterrupted sitting and sitting interrupted with light-intensity or moderate-intensity walking every 20-min (n = 8); and, after three days of either uninterrupted sitting or light-intensity walking interruptions (n = 5). Contraction- and insulin-mediated glucose uptake signaling pathways as well as changes in oxidative phosphorylation proteins were examined. We showed that 1) both interventions reduce postprandial glucose concentration, 2) acute interruptions to sitting over one day stimulate the contraction-mediated glucose uptake pathway, 3) both acute interruptions to sitting with moderate-intensity activity over one day and light-intensity activity over three days induce a transition to modulation of the insulin-signaling pathway, in association with increased capacity for glucose transport. Only the moderate-intensity interruptions resulted in greater capacity for glycogen synthesis and likely for ATP production. These observations contribute to a mechanistic explanation of improved postprandial glucose metabolism with regular interruptions to sitting time, a promising preventive strategy for metabolic diseases.

Indexed as

Sedentary BehaviorAcetyl-CoA CarboxylaseBlood GlucoseGlucoseGTPase-Activating ProteinsHumansInsulinMiddle AgedMuscle ContractionMuscle, SkeletalOxidative PhosphorylationPhosphorylationPostprandial PeriodProto-Oncogene Proteins c-aktACACA protein, humanAcetyl-CoA CarboxylaseBlood GlucoseGlucoseGTPase-Activating ProteinsInsulinProto-Oncogene Proteins c-aktTBC1D4 protein, human

Identifiers

PMID27554943
PMCPMC4995429
OpenAlexW2512124094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.