Evidence map›Paper›PMID 27554823›Full record

ArticleThe Journal of allergy and clinical immunology2016

Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma.

Erik B Hysinger, Jeffrey D Roizen, Frank D Mentch, Lyam Vazquez, John J Connolly, Jonathan P Bradfield, Berta Almoguera, Patrick M Sleiman, Julian L Allen, Michael A Levine and 1 more

Open access · bronzeAbstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2020
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Erik B HysingerCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa; Division of Pulmonary Medicine, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Jeffrey D RoizenDivision of Endocrinology and Diabetes, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Frank D MentchCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Lyam VazquezCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa.
John J ConnollyCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Jonathan P BradfieldCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Berta AlmogueraCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa.
Patrick M SleimanCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa.
Julian L AllenDivision of Pulmonary Medicine, the Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa.
Michael A LevineDivision of Endocrinology and Diabetes, the Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa.
Hakon HakonarsonCenter for Applied Genomics, the Children's Hospital of Philadelphia, Philadelphia, Pa; Division of Pulmonary Medicine, the Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa. Electronic address: hakonarson@email.chop.edu.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Career Development Program in Pediatric Diabetes Research (K12) at CHOPK12DK094723 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI WILLI, STEVEN M · 2011 to 2020
$3.6M
Regulation of serum vitamin D (calcidiol - 25(OH)D) by CYP2R1K08HD087964 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROIZEN, JEFFREY DAVID · 2016 to 2018
$388k
NICHD NIH HHS K08 HD087964NIDDK NIH HHS K12 DK094723
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AsthmaCase-Control StudiesChildCross-Sectional StudiesFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID27554823
PMCPMC5526345
OpenAlexW2510312690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.