Evidence map›Paper›PMID 27554797›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2017

Microbiota as a mediator of cancer progression and therapy.

Jillian L Pope, Sarah Tomkovich, Ye Yang, Christian Jobin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.

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  8. Frontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jillian L PopeDepartment of Medicine, University of Florida, Gainesville, Fla.
Sarah TomkovichDepartment of Medicine, University of Florida, Gainesville, Fla; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Ye YangDepartment of Medicine, University of Florida, Gainesville, Fla.
Christian JobinDepartment of Medicine, University of Florida, Gainesville, Fla; Department of Infectious Diseases and Pathology, University of Florida, Gainesville, Fla. Electronic address: christian.jobin@medicine.ufl.edu.
University of Florida · USUniversity of North Carolina at Chapel Hill · US

Funding

The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Impact of microbiota-mediated biotransformation of black tea polyphenolsR01AT008623 · NCCIH · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN, SANG, SHENGMIN · 2015 to 2019
$2.1M
NCCIH NIH HHS R01 AT008623NIDDK NIH HHS R01 DK073338
6 · The paper itself

Abstract

Complex and intricate circuitries regulate cellular proliferation, survival, and growth, and alterations of this network through genetic and epigenetic events result in aberrant cellular behaviors, often leading to carcinogenesis. Although specific germline mutations have been recognized as cancer inducers, the vast majority of neoplastic changes in humans occur through environmental exposure, lifestyle, and diet. An emerging concept in cancer biology implicates the microbiota as a powerful environmental factor modulating the carcinogenic process. For example, the intestinal microbiota influences cancer development or therapeutic responses through specific activities (immune responses, metabolites, microbial structures, and toxins). The numerous effects of microbiota on carcinogenesis, ranging from promoting, preventing, or even influencing therapeutic outcomes, highlight the complex relationship between the biota and the host. In this review, we discuss the latest findings on this complex microbial interaction with the host and highlight potential mechanisms by which the microbiota mediates such a wide impact on carcinogenesis.

Indexed as

Disease ProgressionMicrobiotaAnimalsCarcinogenesisDietDysbiosisHumansNeoplasms

Identifiers

PMID27554797
PMCPMC5674984
OpenAlexW2479524302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.