ArticleCancer prevention research (Philadelphia, Pa.)2016
Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.
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Article in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans.Brain, behavior, and immunity · 2024Trial
- Effects of fish oil supplementation on eicosanoid production in patients at higher risk for colorectal cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2019Trial
- Prophylactic and therapeutic effects of aspirin in cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- A secondary analysis of a prospective cohort study: association between aspirin regime and early- and late-onset preeclampsia.BMC pregnancy and childbirth · 2026Article
- Regorafenib and metronomic capecitabine, cyclophosphamide, and aspirin in refractory metastatic colorectal cancer: results from the REPROGRAM-01 single-arm phase II trial.ESMO gastrointestinal oncology · 2025Article
- Application of Mendelian randomization analysis to explore causal associations of aspirin use with bone mineral density and risk of fracture.Hereditas · 2025Article
- Aspirin in Cancer Therapy: Pharmacology and Nanotechnology Advances.International journal of nanomedicine · 2025Review
- Cancer Metastases to the Liver: Mechanisms of Tumor Cell Colonization.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The role of aspirin in preventing gastrointestinal cancers.Gastrointestinal oncology (Philadelphia, Pa.) · 2024Review
- Review
- Colorectal cancer chemoprevention: is aspirin still in the game?Cancer biology & therapy · 2022Review
- Low dose aspirin associated with greater bone mineral density in older adults.Scientific reports · 2022Article
- Teaching an old dog new tricks: Drug discovery by repositioning natural products and their derivatives.Drug discovery today · 2022Review
- Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases.Bioscience reports · 2022Article
- Effects of dietary aspirin on high-LET radiation-induced prostaglandin E2 levels and gastrointestinal tumorigenesis in ApcLife sciences in space research · 2021Article
- Mining drug-target and drug-adverse drug reaction databases to identify target-adverse drug reaction relationships.Database : the journal of biological databases and curation · 2021Article
- The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID-19 infection.The FEBS journal · 2021Article
- Aspirin as an Adjunctive Pharmacologic Therapy Option for COVID-19: Anti-Inflammatory, Antithrombotic, and Antiviral Effects All in One Agent.Journal of experimental pharmacology · 2021Article
- Multifaceted Functions of Platelets in Cancer: From Tumorigenesis to Liquid Biopsy Tool and Drug Delivery System.International journal of molecular sciences · 2020Review
- miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells.Oncotarget · 2020Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Olivier BoutaudDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee. olivier.boutaud@vanderbilt.edu.
I Romina SosaDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Taneem AminDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Denise OramDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
David AdlerDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Hyun S HwangDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Brenda C CrewsDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Ginger MilneDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Bradford K HarrisDepartment of Cancer Biology; and the Thoracic Program, Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Megan HoeksemaDepartment of Cancer Biology; and the Thoracic Program, Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Bjorn C KnollmannDepartment of Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Philip E LammersDepartment of Cancer Biology; and the Thoracic Program, Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Lawrence J MarnettDepartment of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Pierre P MassionDepartment of Cancer Biology; and the Thoracic Program, Vanderbilt Ingram Cancer Center, School of Medicine, Vanderbilt University, Nashville, Tennessee.
John A OatesDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Baylor College of Medicine · US
Funding
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Maureen Sanderson · 2017 to 2026
$48.2MTARGETING NOTCH 3 IN LUNG CANCERP50CA090949 · NCI · VANDERBILT UNIVERSITY · PI MASSION, PIERRE P. · 2001 to 2011
$24.1MTranslational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI BALLARD, BILLY RAY · 2011 to 2025
$18.8MVanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9MTHE PHARMACOLOGY OF ASPIRINP50HL081009 · NHLBI · VANDERBILT UNIVERSITY · PI LIEBLER, DANIEL · 2006 to 2010
$16.3MTHE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1985 to 2010
$15.0MValidation of Biomarkers of Risk for the Early Detection of Lung CancerU01CA152662 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEPPEN, STEPHEN, GROGAN, ERIC L · 2010 to 2025
$12.8MCLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4MTherapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5MFUNCTIONAL ANALYSIS OF CYCLOOXYGENASE 2R01CA089450 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2001 to 2016
$6.3MTroponin T mutations and Sudden Cardiac DeathR01HL071670 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2003 to 2017
$4.5MCalsequestrin in Ventricular Arrhythmia and Sudden DeathR01HL088635 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2007 to 2015
$3.2MAmerican Heart Association-American Stroke Association 12SDG12050597American Heart Association-American Stroke Association 13FTF17400011NCI NIH HHS K12 CA090625NCI NIH HHS P50 CA090949NCI NIH HHS R01 CA089450NCI NIH HHS R01 CA102353NCI NIH HHS R01 CA163772NCI NIH HHS U01 CA152662NCI NIH HHS U54 CA163069NHLBI NIH HHS P50 HL081009NHLBI NIH HHS R01 HL071670NHLBI NIH HHS R01 HL088635NHLBI NIH HHS R01 HL124935NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431NIGMS NIH HHS T32 GM007569
Abstract
Meta-analyses have demonstrated that low-dose aspirin reduces the risk of developing adenocarcinoma metastasis, and when colon cancer is detected during aspirin treatment, there is a remarkable 83% reduction in risk of metastasis. As platelets participate in the metastatic process, the antiplatelet action of low-dose aspirin likely contributes to its antimetastatic effect. Cycloxooxygenase-2 (COX-2)-derived prostaglandin E
Indexed as
AdenocarcinomaAdultAspirinCell Line, TumorCyclooxygenase 2Cyclooxygenase InhibitorsDinoprostoneFemaleHumansMaleNeoplasm InvasivenessAspirinCyclooxygenase 2Cyclooxygenase InhibitorsDinoprostone
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