Evidence map›Paper›PMID 27554619›Full record

ArticleStem cells and development2016

A Novel High-Throughput Screening Platform Reveals an Optimized Cytokine Formulation for Human Hematopoietic Progenitor Cell Expansion.

Marina Tarunina, Diana Hernandez, Barbara Kronsteiner-Dobramysl, Philip Pratt, Thomas Watson, Peng Hua, Francesca Gullo, Mark van der Garde, Youyi Zhang, Lilian Hook and 2 more

Abstract read
In one paragraph

Article in Stem cells and development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. From iPSC to manufactured iNK cells using CombiCult® screening platform.Frontiers in cell and developmental biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Marina Tarunina1 Plasticell Ltd. , Stevenage Bioscience Catalyst, Stevenage, United Kingdom.
Diana Hernandez1 Plasticell Ltd. , Stevenage Bioscience Catalyst, Stevenage, United Kingdom.
Barbara Kronsteiner-Dobramysl2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .
Philip Pratt4 Department of Surgery and Cancer, Faculty of Medicine, Imperial College London , South Kensington, United Kingdom .
Thomas Watson1 Plasticell Ltd. , Stevenage Bioscience Catalyst, Stevenage, United Kingdom.
Peng Hua2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .
Francesca Gullo2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .
Mark van der Garde2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .
Youyi Zhang2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .
Lilian Hook1 Plasticell Ltd. , Stevenage Bioscience Catalyst, Stevenage, United Kingdom.
Yen Choo1 Plasticell Ltd. , Stevenage Bioscience Catalyst, Stevenage, United Kingdom.
Suzanne M Watt2 Stem Cell Research, Nuffield Division of Clinical Laboratory Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford , Oxford, United Kingdom .

Funding

Department of Health RP-PG-0310-1003
6 · The paper itself

Abstract

The main limitations of hematopoietic cord blood (CB) transplantation, viz, low cell dosage and delayed reconstitution, can be overcome by ex vivo expansion. CB expansion under conventional culture causes rapid cell differentiation and depletion of hematopoietic stem and progenitor cells (HSPCs) responsible for engraftment. In this study, we use combinatorial cell culture technology (CombiCult

Indexed as

AC133 AntigenAlginatesAlgorithmsCell AdhesionCell ProliferationCytokinesFlow CytometryGlucuronic AcidHematopoietic Stem CellsHexuronic AcidsHigh-Throughput Screening AssaysHumansMicrospheresNanofibersReproducibility of ResultsTissue ScaffoldsAC133 AntigenAlginatesCytokinesGlucuronic AcidHexuronic Acidsalginate encapsulationCombiCultex-vivo expansionhematopoietic stem/progenitor cellshigh-throughput-screening

Identifiers

PMID27554619
PMCPMC5105341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.