ArticleJournal of neurotrauma2017
Cerebral Perfusion Changes in Post-Concussion Syndrome: A Prospective Controlled Cohort Study.
Article in Journal of neurotrauma, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review of ASL Perfusion MRI in Mild TBI.Neuropsychology review · 2023Pooled it
- Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils.Neuroscience and biobehavioral reviews · 2018Pooled it
- Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review.NeuroRehabilitation · 2018Pooled it
- Behavioral Deficits and Cortical Network Dysfunction Following Repeated Mild Traumatic Brain Injuries.Journal of neurotrauma · 2026Article
- Neurovascular coupling dysfunction of the frontal‒thalamic circuit in postconcussion syndrome.Brain imaging and behavior · 2026Article
- Persistent dysmorphology and dysfunction of the brain microvasculature following repeated trauma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- The Role of MRI in Debunking the Fallacy of "Mild" Traumatic Brain Injury.Journal of magnetic resonance imaging : JMRI · 2026Review
- Combined Human Neural Stem Cell and Structured Treadmill Walking Therapy Enhances Recovery in a Pediatric Porcine Traumatic Brain Injury Model.Journal of neurotrauma · 2025Article
- Psychiatric outcomes after mild concussion by treatment timing and age.Journal of psychiatric research · 2025Observational
- Patterns of Use and Benefit of Triptans in the Treatment of Acute Headache Worsening in Youth With Post-Traumatic Headache.Pediatric neurology · 2025Article
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Alterations of cerebrovascular reactivity following pediatric mild traumatic brain injury are independent of neurodevelopmental changes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- American Headache Society white paper on treatment of post-traumatic headache from concussion in youth.Headache · 2024Article
- Article
- Does Physiologic Post-Concussion Disorder Cause Persistent Post-Traumatic Headache?Current pain and headache reports · 2023Review
- Multispectral optoacoustic tomography (MSOT): Monitoring neurovascular changes in a mouse repetitive traumatic brain injury model.Journal of neuroscience methods · 2023Article
- A Scoping Review of Magnetic Resonance Modalities Used in Detection of Persistent Postconcussion Symptoms in Pediatric Populations.Journal of child neurology · 2023Article
- Arterial spin labeling magnetic resonance evaluates changes of cerebral blood flow in patients with mild traumatic brain injury.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Sub-acute Changes on MRI Measures of Cerebral Blood Flow and Venous Oxygen Saturation in Concussed Australian Rules Footballers.Sports medicine - open · 2022Article
- Multimodal magnetic resonance imaging of youth sport-related concussion reveals acute changes in the cerebellum, basal ganglia, and corpus callosum that resolve with recovery.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The biology of post-concussive symptoms is unclear. Symptoms are often increased during activities, and have been linked to decreased cerebrovascular reactivity and perfusion. The aim of this study was to examine cerebral blood flow (CBF) in children with different clinical recovery patterns following mild traumatic brain injury (mTBI). This was a prospective controlled cohort study of children with mTBI (ages 8 to 18 years) who were symptomatic with post-concussive symptoms at one month post-injury (symptomatic, n = 27) and children who had recovered quickly (asymptomatic, n = 24). Pseudo continuous arterial spin labeling magnetic resonance imaging (MRI) was used to quantify CBF. The mTBI groups were imaged at 40 days post-injury. Global and regional CBF were compared with healthy controls of similar age and sex but without a history of mTBI (n = 21). Seventy-two participants (mean age: 14.1 years) underwent neuroimaging. Significant differences in CBF were found: global CBF was higher in the symptomatic group and lower in the asymptomatic group compared with controls, (F(2,69) 9.734; p < 0.001). Post-injury symptom score could be predicted by pre-injury symptoms and CBF in presence of mTBI (adjusted R
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