Evidence map›Paper›PMID 27554424›Full record

ArticleJournal of electrocardiology

Electrocardiographic predictors of mortality and sudden cardiac death in patients with end stage renal disease on hemodialysis.

Jonathan W Waks, Larisa G Tereshchenko, Rulan S Parekh

Open access · greenAbstract read
In one paragraph

Article in Journal of electrocardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Effects of MarineNutrients · 2018
    Trial
  2. Assessing arrhythmic risk in chronic kidney disease: A study of the index of cardiac-electrophysiological balance.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
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  12. Uraemic Cardiomyopathy: A Review of Current Literature.Clinical Medicine Insights. Cardiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Jonathan W WaksDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Larisa G TereshchenkoKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.
Rulan S ParekhDivision of Nephrology, Hospital for Sick Children, University Health Network and University of Toronto, Toronto, Ontario, Canada. Electronic address: rulan.parekh@sickkids.ca.
Beth Israel Deaconess Medical Center · USOregon Health & Science University · USSickKids Foundation · CA

Funding

Novel ECG Measures and Risk of Sudden Cardiac DeathR01HL118277 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TERESHCHENKO, LARISA GENNADIEVNA · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL118277
6 · The paper itself

Abstract

Patients with end stage renal disease (ESRD) on hemodialysis experience a high incidence of cardiovascular mortality, and sudden cardiac death (SCD) accounts for approximately 25% of all deaths in this patient population. Despite this high risk of SCD, many non-invasive SCD risk stratification tools that are frequently applied to other patient populations (such as those with prior myocardial infarction and reduced left ventricular systolic function) may be less useful markers of increased SCD risk in ESRD. Improved SCD risk stratification tools for use specifically in patients on hemodialysis are therefore necessary to optimally target use of primary prevention interventions aimed at decreasing SCD incidence. Electrocardiography is an effective, non-invasive SCD risk stratification tool in hemodialysis patients. This article reviews data supporting the association between various ECG parameters (QT interval, spatial QRS-T angle, signal averaged ECG, heart rate variability, and T-wave alternans) and mortality/SCD in the dialysis population. Despite the association between abnormal ECG parameters and SCD, it remains unclear if these abnormal parameters (such as prolonged QT interval) are mechanistically related to SCD and/or ventricular arrhythmias, or if they are simply markers for more severe cardiac disease, such as left ventricular hypertrophy, that may independently predispose to SCD. Current obstacles that impair widespread implementation of ECG risk stratification in the hemodialysis population are also discussed.

Indexed as

Cardiac Conduction System DiseaseCausalityComorbidityDeath, Sudden, CardiacElectrocardiographyFemaleHumansIncidenceKidney Failure, ChronicMalePrognosisRenal DialysisReproducibility of ResultsRisk FactorsSensitivity and SpecificitySurvival AnalysisArrhythmiaCardiovascular diseaseConduction abnormalityElectrocardiogramEnd stage renal diseaseHemodialysisSudden cardiac death

Identifiers

PMID27554424
PMCPMC5159311
OpenAlexW2483629759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.