ArticleTransgenic research2017
Generation of α-1,3-galactosyltransferase knocked-out transgenic cloned pigs with knocked-in five human genes.
Article in Transgenic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Case Report: Left ventricular hemorrhage associated with early neonatal mortality in multi-gene engineered cloned pigs.Frontiers in veterinary science · 2026Article
- Targeted knock-in of human immune-regulatory genes into the porcine GGTA1 exon 4 reveals divergent expression on red blood cell membranes.Scientific reports · 2025Article
- Construction and Characterization of Immortalized Skin Fibroblasts from Milu Deer.Animals : an open access journal from MDPI · 2025Article
- Genomic imprinting at a porcine ZNF locus via a canonical imprinting mechanism.Animal genetics · 2025Article
- A bibliometric mapping of advancements and trends in genome editing in pigs.Tropical animal health and production · 2025Review
- Short Communication: The imprinted and paternally expressed MIMT1 lncRNA ortholog in pigs.Journal of animal science · 2025Article
- Genetically modified pigs with α1,3-galactosyltransferase knockout and beyond: a comprehensive review of xenotransplantation strategies.Frontiers in immunology · 2025Review
- Immunoprotection Strategies in β-Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Characterization of Enlarged Tongues in Cloned Piglets.Current issues in molecular biology · 2023Article
- Cardiac xenotransplantation: from concept to clinic.Cardiovascular research · 2023Review
- The AIRN lncRNA is imprinted and paternally expressed in pigs.Journal of animal science · 2023Article
- A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model.Scientific reports · 2022Article
- Loss of Monoallelic Expression ofFrontiers in genetics · 2022Article
- Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing HumanInternational journal of molecular sciences · 2021Article
- Extranuclear Inheritance of Mitochondrial Genome and Epigenetic Reprogrammability of Chromosomal Telomeres in Somatic Cell Cloning of Mammals.International journal of molecular sciences · 2021Review
- The Landscape of Genomic Imprinting at the PorcineG3 (Bethesda, Md.) · 2020Article
- Review
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- Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation.Animal frontiers : the review magazine of animal agriculture · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent progress in genetic manipulation of pigs designated for xenotransplantation ha6s shown considerable promise on xenograft survival in primates. However, genetic modification of multiple genes in donor pigs by knock-out and knock-in technologies, aiming to enhance immunological tolerance against transplanted organs in the recipients, has not been evaluated for health issues of donor pigs. We produced transgenic Massachusetts General Hospital piglets by knocking-out the α-1,3-galactosyltransferase (GT) gene and by simultaneously knocking-in an expression cassette containing five different human genes including, DAF, CD39, TFPI, C1 inhibitor (C1-INH), and TNFAIP3 (A20) [GT
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.